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4-Acetoxy-DMT Examined:

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Cognitive Heart

Cognitive Heart

Experienced member
OG Pioneer
4-Acetoxy-DMT Examined: *Includes safety data sheet.* Simply search substance name. ^

Hopefully this thread can help open the door into this fascinating compound as well as unlock the previous and further mentioned sub-forums for this particular compound.

4-Acetoxy-DMT - DMT-Nexus Wiki

wiki.dmt-nexus.me wiki.dmt-nexus.me


Interesting data broken down into sub sections: Consider and tread carefully before choosing to use these substances.


O-Acetylpsilocin (also known as Psilacetin, 4-Acetoxy-DMT, or 4-AcO-DMT) is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin. However, many report that O-Acetylpsilocin's effects differ greatly from that of psilocybin and psilocin. It is the acetylated form of the psilocybin mushroom alkaloid psilocin, and is a lower homologue of 4-AcO-DET, 4-AcO-MiPT and 4-AcO-DiPT.

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O-Acetylpsilocin can be obtained by acetylation of psilocin under alkaline or strongly acidic conditions. It is a synthetic compound. However, it is believed to be a prodrug of psilocin, which is natural and occurs in many mushrooms along with psilocybin. O-Acetylpsilocin is more resistant than psilocin to oxidation under basic conditions due to its acetoxy group. While O-acetylpsilocin is not well researched (considered by many to be a research chemical, as opposed to psilocin and psilocybin), it is not as difficult to produce as psilocybin, and may be an appropriate substitute for psilocybin in psychedelic research because of their similar mechanism of action.

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O-Acetylpsilocin (psilacetin) and several other esters of psilocin were patented on January 16, 1963 by Sandoz Ltd. via Albert Hofmann & Franz Troxler (US Patent # 3,075,992). Despite this fact, psilacetin remains a psychedelic with a limited history of use. It is theorized to be a prodrug for psilocin, as is psilocybin, which is naturally occurring in various mushrooms. Psilacetin is O-acetylated psilocin, whereas psilocybin is O-phosphorylated.

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In the body O-acetylpsilocin is deacetylated to psilocin by deacetylases/acetyltransferases during first pass metabolism[citation needed] and during subsequent passes through the liver (evident as psilacetin is also active via parenteral routes of ingestion). Its ability to alter cellular metabolism by competing for the deacetylase enzyme causes a perceptible loss of cellular heat generation capacity at doses between 0.4 and 0.8mmol.

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Claims of subjective differences in effect between the acetylated and not acetylated forms of psilocin; some users report that O-acetylpsilocin lasts slightly longer; others report that it lasts for a considerably shorter time. Many users report less body load and nausea compared to psilocin. Some users find that the visual distortions produced by O-acetylpsilocin more closely resemble those produced by DMT than those produced by psilocin. These differences could be possible if psilacetin is active itself and not merely as a prodrug.

...

See & Read More Here:

O-Acetylpsilocin - Wikipedia

Here:

4-AcO-DMT

And Here:

Erowid 4-Acetoxy-DMT Vault
 

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Within including all necessary components towards the safety and well-being of what this drug actually is and how it theoretically works, I've decided to bioassay forthcoming experiences with this mysterious and very interesting synthetic drug. 4-AcO-DMT rapidly converts and metabolizes at the cellular level and opens one to the realm of highly colorful, clear, smooth and reliable effects that are very similar yet quite distinct from that of psilocybin mushrooms and DMT.

I'd like to thank David E.Nichols for his extraordinary work and devotion to such compounds and his findings of (hopefully) using 4-AcO-DMT as an alternative, therapeutic substance for phosphorylated psilocin. In this case, acetylated 4-AcO-DMT fumarate.

This drug is known as 'electric psilocin.' In contrast to my experience so far, I can agree. :)

--

I shall begin with my first experience with 5mg(threshold): Material is assured of quality including but not limited to MSDS sheets, purity % and extensive analysis.

Setting: bedroom and various outdoor places
Time: afternoon
Mood: excitement, nervousness and eagerness
SE's noted throughout experiences: slight disorientation, insomnia, jaw tension, and some derealization.

--

After eating a wholesome meal, I continued to carefully encapsulate one vegetable capsule with 5mg of 4-Acetoxy-DMT. Through the course of an hour of assimilating the food, I then took the capsule with some water. [*Note* This stuff tastes very metallic and alien! It looks incredibly crystalline and fluffy.]

I noticed first effects at around the 10 min marker. My body began to feel fuzzy with this feeling of emerging energy. Typical psychedelic/tryptamine effects onsetting. It was a familiar feeling. My mind and perception began to take on a rather lighter, softer and very spontaneous feeling. Some slight disorientation.

At 45 min I was feeling all the above but much more detailed and surprising. Visual phenomena has started and is quite rapid in appearance, motion, color and vibration. Shapes and forms seem to intertwine and connect to each other. I'm also feeling much more aware and intelligent of my surroundings and situation. My thoughts have increased in flow and direction, leading me to many questions and directions as to why life is. I'm already impressed.

At 1.5 hours I am feeling all the above but completely free and open, amazing body feeling, and I am observing some mild yet very sharp CEV and OEV. Lots of laughter and complexity! Jaw is feeling tense and my mouth and tongue feel really good for some odd reason. This realm is teasing me in a way I can hardly describe due to the rapid flow of ideas.

At 2.5 hours(peak) I am feeling all the above but very sensual now. Nice bodily upliftment. Music is much more visual and greater sounding. I am tripping. Feeling dreamy, euphoric and tired. Everything is more interesting than it actually is. Accelerated thoughts are prominent. A new focus has emerged within my perception and well-being. Giggling is very prominent. The overall tone of this drug is spectacular! Objects and walls appear to be mildly breathing. Some warping and rippling in my peripheral vision. My enhanced state is like no other state I've been in. It is as if the natural enhancing effects of this drug enhance other effects simultaneously and synergistically.

At 4.5 hours I've dropped from the peak and currently feeling a lot of energy to do something. I walk with a friend to go play some music at this old court house we rented out. On the walk there, everything seemed so much more alive and playful. Everything was more appealing but in a very natural, flowing way. Walking was easy as the distorted effects have worn off. Starting to get a mild headache. Playing music hasn't been that easy in a while. High energy and continual playing for almost 2 hours. It was amazing!

At 6 hours all psychoactive effects have settled and am left with a mild headache which lasted for 24 hours afterwards. Some slight digestive changes, too. Some trouble falling asleep.

I am now left in reflection. Afterglow is highly noticeable with few SE's. I can only assume that higher dosages may lead to other possible SE's.

--

All in all, this drug has huge potential as an alternative to mushrooms(or even DMT). However, further research and studies on individual health needs to be addressed. It is already clear that this substance works very similar, if not greater than the desired effects of mushrooms. With only taking 5mg so far, it is difficult to determine anything else. Also, it is quite clear with micro dosing that it efficiently raises energy levels, enhances visual acuity, decision making and reduces stress. Very suitable for enhancing and improving the desire to do activities. :thumb_up:
 
This section extends a fresh report of 15mg(common) orally:

Setting: bedroom, kitchen, bathroom
Time: afternoon
Mood: happy, neutral, lotsa good energy
SE's: headache, teary eyes
*Note* It has become clear to me that this particular drug works in waves, meaning each set of effects increases with intensity and prominence every 10 min or so.

--

Upon the hour of 12:45pm, I ingested 15mg on relatively low stomach and remained inside to enjoy the trip safely. So, after ingestion I then continued to read for a little bit, browse the internet and take a hit of cannabis. Initially, I felt the first effect take hold at around 10 min.. slight buzzing, improvements in vision, and a general fuzziness to everything. Sounds appear to connect to other sounds quite smoothly. Visual distortions of observable movements are appearing in many shapes and forms. Almost as if they are all binding together. Music sounds lovely! I feel the need to use the restroom quite often (urination).

At 25 min everything said above (besides urination) but colorful and getting much deeper in tone. Everything is increasing in interest, especially common objects and natural things.. I can feel them all around.

At 45 min I feel awesomely pleasant. Sense of opening begins. Visuals are mild-moderate and getting stronger and stronger. Highly colorful and enhanced coherency with thought, connectedness of something, laughing and melting in bliss, giggling, feelings of merging with the universe are beginning strongly. My body feels fuzzy and fragile. Music sounds amazing and very detailed. Intensity is rising sharply and slowly. 😁

At 1 hour, 45 min, I feel as if the universe is starting to tear open, visuals prominent and detailed. My environment is melting, breathing, blending, morphing and shifting in colors and intensity. I can see shapes and transformations begin to overlap my vision. Very clear, open and bright experience so far. Visuals(CEV & OEV) are colorful, wavy, spiraled, geometric and brightly lit and trailed. My sense of time is completely distorted! Waves of my hand leave clear and beautiful trails.. :love:

At 2 hours, 50 min, I am soaring through highly detailed visions and highly bright dimensions. Very unique and powerful trailing effects. I am unable to get up and move around. My bed feels amazing and comforting, as is this realm. I am having realizations float out of beautiful panels of light that transform into massive webs of introspection, peace and acceptance. Incredible! Feeling bursts of sensations and deeper understandings unfold before me. Euphoria is present throughout most of this trip with a long, trailing mood lift. Sounds are contrasting and some synesthesia is present but not too strong.

At 3.5 hours, I am literally not here, nor there.. nor anywhere. I feel at one with some kind of source I am familiar with but yet hardly know. I am breaking through some kind of outward vortex ring of space and time.. I can see ripples of florescent patterns and this kind of chrysanthemum ball of energy or light opening infinitely in plain sight. It is appearing all so spontaneously! As I begin to sense what is happening, I then went through something quite fast and out back through myself. :?: This utter sense of bliss, joy and deep peace quickly bolted me up out of my bed and I said to myself, "holy s***." This was hyper-arousal! This very strong sense of rushing! :want:

Visuals have peaked and are slowly appearing farther away. I then began to do a lot of cleaning around the house. Mostly in the kitchen where I left a pile of mess earlier. Actually, I accomplished a lot. That is when I realized how hungry I was and enjoyed a nice feast I made. Taste was highly detailed and sharp.. immersed senses!

At 4-5.0 hours I am tearing to how beautiful the peak was and I am very happy and motivated! I have this very clear sense of energy.. or rather a realization of anew.. a kind of transcendence.. some kind of reset occurred. Almost felt like I died physically after I broke through this spectacular, space time thing and back through myself. Definitely out of my body for some period. Whatever time really is.

At 6.0 hours all effects are starting to baseline. Visuals slowly come to a halt and I am left with this feeling of seeing through new eyes. I have this urge to just enjoy life. I feel free.

This substance can definitely be useful for therapy if used properly.

--

Afterglow: fresh feelings, insights and a sense of energy to just enjoy life. Greater sense of connection and quite honestly, similar to a mushroom afterglow state yet clearer. I can feel a headache come on but is absolutely mild to say the least.

I shall continue when I have moar time! :thumb_up:
 
Sounds like a really interesting experience, thanks for sharing that!

I noticed you mentioned headaches with it. Was that throughout or during a certain part of the experience? And how intense? Is this something that you have noticed happening with mushrooms to? Just curious really. I don't get them personally but I know that some do get slight headaches with mushrooms at times.
 
This is such a lovely chemical indeed. Ive had many blissful journeys at 30mg of this.
My last one was at about 60mg but it was still very managble although very intense.

I actually prefer this to mushrooms since its got a alot gentler bodyload for me.
I still would like to try +5g doses of cubensis but even at 3g i get severe back pain from the vasoconstriction.
 
universecannon said:
Sounds like a really interesting experience, thanks for sharing that!
I noticed you mentioned headaches with it. Was that throughout or during a certain part of the experience? And how intense? Is this something that you have noticed happening with mushrooms to? Just curious really. I don't get them personally but I know that some do get slight headaches with mushrooms at times.
Click to expand...

Your welcome! :)

Through all these experiences, mild headaches after the initial trip was occasional. Although only have occurred twice, mushrooms usually will give me a headache no matter what the dosage is, usually on onset or within the afterglow. Again though, quite mild and dissipates quickly.

--

Infectedstyle said:
" *Note* At 10 hours; I think this drug can be useful for therapy if used properly. "
Hah, no kidding Very happy
Click to expand...

Ha hah! Indeed..on that note, thank you David Nichols once again! 😁

--

SHroomtroll said:
This is such a lovely chemical indeed. Ive had many blissful journeys at 30mg of this.
My last one was at about 60mg but it was still very managble although very intense.
I actually prefer this to mushrooms since its got a alot gentler bodyload for me.
I still would like to try +5g doses of cubensis but even at 3g i get severe back pain from the vasoconstriction.
Click to expand...

I'm happy to know of your experiences with it. I am quite excited to reach those much higher dosages. Can you relate to insufflation? Although it is similar to mushrooms in many ways, I feel it is much closer to that of the DMT experience (from reports) and works incredibly efficiently within the body with virtually no SE's. I've only gone as far 3.5g's of mushrooms.

--

Purges said:
Have to say this seems like a fantastic molecule! Will keep my eye on this thread
Click to expand...

Yes, stay tuned my friends! ;)

*Note* - 10mg and 20mg reports have been removed. 10mg orally at night hardly had any effect, if any. 20mg orally in the afternoon was a beautiful experience, but did not sufficiently provoke me in anyway, but was the most empathic experience with this substance as of yet, with all other effects included. I'd like to add that insufflation may work greater at night due to a rapid onset but shorter duration. Eating a very small meal after ingestion of 4-Aco may prove worthy as well.
 
I've only fairly recently been introduced to this amazing substance. I agree that I prefer it to mushrooms for many of the same reasons described by others- less bodyload, zero nausea. Not as sedating in nature as mushrooms. Much more crisp DMT like visuals, although still a "shroomy" feel to it if that makes any sense. More easily controlled dosage. I have noticed a bit of a headache with it too, although I've never really noticed a headache with mushrooms.

Since first having tried this a few months ago, I haven't done mushrooms at all.

The first time I tried it, I had already taken some ayahuasca that was not particularly strong. We decided to boost 15 mg each of 4aco. It really gave me quite a great rush. I felt like I was in a rocket ship blasting off or something. It was so great that after an undetermined amount of time (30-60 minutes maybe), we decided to boost another 15 mg each. It synergized just perfectly with the not very strong ayahuasca. Very nice time.
 
Hi nicechrisman! Thanks for sharing. Your description is right on. :)

I cannot agree or say whether I prefer it to mushrooms or not. With mushrooms, a very particular and familiar feeling is felt within this kind of earth - universal consciousness, that just seems like home in regards to psilocybin prodrugs, which are so vastly different and complex in their nature of experience from mushrooms. I do agree that the overall effects are much clearer and manageable than that of mushrooms, and quite DMT-like with waves of mushroom-like effects.

Do you recall which kind of bark you were utilizing? Seemed like the perfect timing for you, congrats! :thumb_up:
 
Bump.

Reporting back on my recent 8mg fumarate oral experience with this substance, which unfolded slightly stronger than what was initially intended. Not that it really made any real impact but interesting to note; the material I utilized had been sitting in a veggie capsule chalk full of cannabinoid crystals for almost a year, all stuck together. Beautiful merging of crystals. I thought that was neat. At the time I was just storing for later use not knowing about the cannabis xtals but it made for quite the aesthetic in the long term. :d

So this went down last Sunday on October 2nd, early bird morning - 2km trek beforehand. Although it wasn't exactly sunny nor warm. Quite cool and overcast but rain or shine was the deal. A sweater, headwear and long pants does well. As well as a backpack full of survival gear.

9am - Loaded up for the forest hike, fasted for 13 hours, no breakfest - just a tall glass of spring water. Packed little food. Capsule taken roughly half hour after glass of water at around 9:30am. I then made my way within the dense forest and began hiking uphill.

10:45am - About half-way through the trek I started to feel a peculiar yet familiar sedation. I can feel the typical typtamine headspace coming in but quite slowly and gradual. Feeling more grounded and empathic. Some slight movement, breathing and afterimages are in my vision, as well as some shimmering is noticeable. My acuity has sharpened, also. Feeling lighter and slightly heavy. I'm also yawning quite persistently, so something is certainly on its way..

11:30am - I am coming back down from the full circle hike, feeling restored and somewhat energetic but slightly dehydrated. Although some mood lifting and euphoria has set in which helped deter the dehydration. I make my way back to my apartment safely and walk through the front door. The effects were definitely apparent at this point in time. It also just started to pour rain outside so timing was good.

12:05pm - After a vigorous hike and determining the typtamine effects coming in, I decide to take a shower. This is when reality started to tear open a bit. As I walk into the comfort of revitalizing and reliable water, I immediately feel at home. Visually with eyes closed, I can see these purple, friendly tentacle-like bodies with bright, neon eyes breathing and swaying back and forth and also through me. As if they were purging my brain with the water. Much laughter soon followed. My mind begins to flow, connect and merge ideas and curiosities. Some thought confusion was present but I was able to hold it together. The water was hitting and soaking me in insights. I was truly thankful for it. Psychedelics always bring me to this state of gratefulness. Just knowing you are and have enough to be fortunate. ;)

As I finish up my shower I enter out the bathroom door and into the main room. Alteration of color is now greatly perceived. This peak wasn't going to be that strong(or so I thought) so I loaded up some cannabis in a pipe to enhance the rest of the experience. Boy did it ever.. it shouldn't have been no surprise. :roll:

12:45pm - No food for almost 20 hours and feeling incredible. Virtually no hunger. It feels like the tryptamine has supplied my most important meal of the day. 😁 Or perhaps just suppressed it. At this point, however, I am tripping. My jaw has tightened and expression of mouth sounds is enhanced. Music sounds intense as does the beauty of nature outside the window. Some Amazon live sounds was also quite pleasant to listen to. My body is tingling consistently. Visually with eyes open, I can see clear trails leaving my hands. Color saturation is magnified and coming right at me, texturing my state of awareness. Wherever I looked a visual cue would fall right in its place. Some complex patterns are forming around me but certainly to no breakthrough extent, more so fleeting in style. Feeling waves of subjectively different sensations such as joy, creative awe and emptiness, all rolling in and out of my breathing and body. The subtleties of my everyday 'reality' begin to pour in and take hold.

"How did I miss all this?"

It's these kind of experiences that remind me of our lifestyle habits and how we express ourselves within those routines. And how fortunate in even having a balanced routine actually is. The fact I awoke today to experience this cannot be taken for granted.

2:00pm - Feeling immensely purified and relaxed but I need food. I take my time to prepare a light lunch as the tryptamine was still making its way through me. A handful of a few different foods was enough. I can always quantify later.

3:00pm - Orgasm release. Self-explanatory. :lol:

4:00pm - Still not down on any energy or baseline but not tripping, if that makes sense. Actually, kind of nootropic-like activity at this point. That hike performed earlier seemed to have helped a lot with general energy levels, too.

6:00pm - Baseline, afterglow. Final meal prep begins.

Overall, this was a fun yet profound dose to work with. Although a few times during the initial peak the sedation forced me to sit down, I'd be right back up 10-20 min later doing what I normally do but with a vibrant edge to it. It hadn't hindered me in anyway but more or less encouraged me to stay active. Physically, mentally, emotionally, etc. This substance really does work away the cobwebs and 'ordeals' we all face. Although I cannot recommend fasting to everyone, it most certainly assists in lower doses of potent molecules. :)
 
This was from an older thread:

it appears that anytime you want a prodrug of a tryptamine with a hydroxy group at position 4, you can just substitute the hydroxy grouping with an acetoxy grouping, the acetoxy grouping will become a hydroxy grouping in vivo...at least this seems to be the case.

So, 4-acetoxy-DMT becomes 4-ho-DMT in vivo...4-acetoxy-MET becomes 4-ho-MET in vivo, and so on.

Even with 1-acetyl-LSD this seems to be the case, minus the oxygen because you want an NH grouping at position 1, so it's an acetyl grouping rather than an acetoxy grouping. so the acetyl grouping connected to the nitrogen of the pyrrole ring Returns to a hydrogen atom, restoring the NH grouping of the pyrrole ring, giving LSD in vivo.

With 1-propionyl-LSD, just as above, only using a propionyl grouping at position one of LSD, the propionyl grouping becomes the needed hydrogen atom in vivo to form the NH grouping of the pyrrole ring, giving LSD...

I wonder if 4-propionyloxy-DMT would become 4-ho-DMT in vivo...
-eg
Click to expand...

-----

When synthesizing psilocin one starts with 4-acetoxyindole, which is converted to 4-acetoxyindol-3-yl-N,N-dimethylglyoxylamide, which is then converted, by the acetoxy grouping at 4 eventually being converted to the needed HO grouping, to 4-hydroxy-DMT aka psilocin.

So when synthesizing psilocin you start with an acetoxy grouping at 4 (of 4-acetoxyindole) Which is eventually converted to the needed hydroxy group of psilocin...

Just like when one consumes 4-aco-DMT, the acetoxy grouping at position 4 is said to be converted in vivo to the needed hydroxy grouping...

...I love it.

-eg
 
steppa said:
If one had the HCL salt...would one be able to freebase it for means of vaporization?
Click to expand...
From what I understood it is possible, though it has two severe drawbacks:

1) The freebase is quite unstable so will degrade fast over a few days
2) It will not vaporize intact much so it will be very ineffective and basically a waste to use this route


Kind regards,

The Traveler
 
I am quite aware of the psilocin conversion. I do notice a subjectively greater and clear difference between the overall effects of mushrooms and synthetic 4-Acetoxy-DMT. A few reports suggest the body load and lethargy is reduced. I tend to agree. I'm also aware that endlessness has some experience with vaporizing 4-Acetoxy-DMT so they might be knowledgeable on that subject. :)
 
Interesting. Thank you guys.

A while back I tried to freebase a bit of it with baking soda which didn't work.

So...know I looked into it again, just to see that it is NOT the HCL salt. It's labeled as

3-[2-(Dimethylamino)ethyl]-1H-indol-4-yl acetate

Form: Fumarate salt

I'm really interested in short(er) acting vaporizable psychedelics. From the contradicting reports I read about vaporizing 4-ACO, I took that IF it works it would last about 2 hours. This is an interesting time frame for me and I would be thankful for hints on how to proceed to freebase the substance mentioned above.

1) The freebase is quite unstable so will degrade fast over a few days
Click to expand...

Degradation of the freebase wouldn't be an issue for me, as freebasing would happen only "on demand".

It will not vaporize intact much so it will be very ineffective and basically a waste to use this route
Click to expand...

Interesting. I hope endlessness chimes in and can provide some feedback on that.
 
steppa said:
Interesting. Thank you guys.

A while back I tried to freebase a bit of it with baking soda which didn't work.

So...know I looked into it again, just to see that it is NOT the HCL salt. It's labeled as

3-[2-(Dimethylamino)ethyl]-1H-indol-4-yl acetate

Form: Fumarate salt

I'm really interested in short(er) acting vaporizable psychedelics. From the contradicting reports I read about vaporizing 4-ACO, I took that IF it works it would last about 2 hours. This is an interesting time frame for me and I would be thankful for hints on how to proceed to freebase the substance mentioned above.

1) The freebase is quite unstable so will degrade fast over a few days
Click to expand...

Degradation of the freebase wouldn't be an issue for me, as freebasing would happen only "on demand".

It will not vaporize intact much so it will be very ineffective and basically a waste to use this route
Click to expand...

Interesting. I hope endlessness chimes in and can provide some feedback on that.
Click to expand...

The package told you it was the acetate salt...

-eg
 
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