4-Hydroxydimethyltryptamine from DMT?

[weissewolf]

I was just curious if anybody has tried this with success?
I found this in the following article.

Psychedelic Chemistry - Magic Mushrooms and Other Indole Trips

4-Hydroxydimethyltryptamine (Psilocin) from DMT C.R. Acad. Sci. Paris 275,613(1972) See also C.R.A.S.P. 269,51(1969) and BSC 1523(1959).

Mix 0.01 M dimethyltryptamine, 0.02 M phosphate buffer pH 7.2 containing 5 mM ascorbic acid, 0.02 M disodium EDTA and 0.01 M ferrous sulfate (CuCl may substitute) and add with stirring at 20-22ø 0.02M H2O2 (0.01 M may increase yield). Let reaction proceed to completion (2 hours or less) and extract with ethyl acetate. Dry and evaporate in vacuum to get about 30% yield of psilocin. The product, which contains the other OH-DMT's as well, can be chromatographed on silica thin layer with t-butanol-acetic acid-water (ACS 22,1210 (1968)) or on a 5% alumina-Nickel column or 10% alumina-Nickel plate with CHCl3-methanol and the psilocin eluted with methanol.

 

[benzyme]

damn, that seems really simple; never tried (or even heard of) it though

the phosphate buffer is just pH 7 buffer for pH meter calibration, and ascorbic acid is vitamin c.
all those reagents are fairly benign, therefore easily acquired.


though not sure swim would devote any precious spice to such an endeavor. would be cheaper to just grow the little buggers containing 4-HO-DMT

 

[weissewolf]

Yeah but it would be sweet if you could have it in liquid or drop it on paper.

 

[benzyme]

a tincture in an amber bottle (in an anti-oxidant solution like dmso or ascorbic acid) would be cool, but paper would not be a good idea. active doses of psilocin are around 10-15mg so it may not fit (it might on sugar cubes), and psilocin auto-oxidizes in air.

 

[weissewolf]

Yeah I couldnt remember about the oxygen thing. I thought I read about it in tikhal that it broke down in contact with oxygen but wasnt sure.

 

[VisualDistortion]

I would trade in some spice for some pure psilocin

 

[benzyme]

maybe if dmt was already synthed

30% yield is a pretty low yield, yet this seems like a really simple invention

 

[weissewolf]

This isnt from DMT but I found this also. Talks of soxhlet extraction of dried cubes.

Mushroom Extracts | Ask Dr. Shulgin

http://leda.lycaeum.org/?ID=10410

 

[VisualDistortion]

You could keep it in some dmso and then when you wanted some magick, you could inject it into a marshmellow until you had the weight increase you wanted. I say inject it into a marshmellow just to keep oxygen exposure down.