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5-MeO-AMT

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5-MeO-aMT - DMT-Nexus Wiki
Although this specific neurotransmitter [serotonin] is a big item in the brain, if you feed it to a person, or put it into him via the blood or tissue, it can't get there. It has no way of moving this specific molecule from the outside of the brain (the periphery) into the brain itself (the central Kingdom).

Two obstacles effectively prohibit this availability. Serotonin has a free hydroxy group (the 5-hydroxy which is the H of 5-HT). This is a big polar water-loving pimple which denies it any passage across the brain's defensive Maginot Line, the blood-brain barrier. And there is the second problem. There is a exposed amino group, the amine of T of 5-HT, the tryptamine, which is immediately removed by the body's monoamine oxidase enzyme. In short, it is blocked from entry into the brain because it is both too polar and too metabolically fragile.

The structure of alpha-O is designed to overcome these two restrictions. A methyl group on the oxygen (the O-methyl) removes the polarity restriction. A methyl group next to the amine function (the alpha-methyl) protects the molecule from enzymatic attack. With the two obstacles removed, this compound apparently has easy access directly to the brain. Hence, alpha,O-dimethylserotonin (a,O-DMS) goes directly into the central nervous system and has proved to be one of the most potent tryptamines yet described. And it is active following oral administration, where it is exposed to all of the body's protective machinery. TIHKAL;shulgin


First, the concepts and chemistry behind the formulation of this compound is brilliant, and this alone was of interest...

Second, was the experiance produced, even after reading the TIHKAL entry's its still fairly unclear as to the nature of the experiance, which is quite real, and occurs at low dose, 2.5mgs-4.5mgs is incredible potency for a tryptamine compound.

I get the feeling that alpha-0-DMS is not a "true" psychedelic, yet I still feel there is something worth investigating here.

Basically, I just came across this fascinating compound, put it in the "research later" folder, where it sat for years, until my research this morning randomly led me back to it...

-eg
 
If you take phenethylamine, and add a methyl group to the alpha carbon of the ethyl side chain, you get alpha-methyl-phenethylamine also known as "amphetamine"

Now, when you take tryptamine, and add a methyl grouping to the alpha carbon of the ethyl side chain, you get alpha-methyl-tryptamine or "AMT"

Alpha-0-dimethyl-serotonin (alpha-0-DMS) is also known as 5-methoxy-alpha-methyl-tryptamine (5-meo-AMT)

5-meo-AMT has had some use on the recreational drug market, there were even several hospitalizations due to confusions with AMT, some RC companies even had the compounds confused. There was a death involving a woman who believed she had taken LSD, toxicology showed the compound was in fact alpha-0-DMS, so there is obvious risk involved here, and the compound may have earned a bit of a bad name as a result...

Alpha-0-DMS has to be on of the most potent tryptamine compounds I've researched, this stuff is fascinating, but obviously carries risk...

It's still a point in my research none the less...

-eg
 
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