entheogenic-gnosis
Rising Star
I have been researching medical use of dimethyltryptamine homologues and bioisosteres, and every day I find another compound with a dimethyltryptamine skeleton that has medical applications.
We all know about the obvious medical dimethyltryptamine compounds, such as the triptan compounds (zolmatriptan, sumatriptan, etc...) and most have probably read about the potential medical uses of brominated dimethyltryptamine compounds found in some sea invertabrates, but this compound stood out to me, specially in its purported claims to improve memory and brain function.
Anyone with information on this or other dimethyltryptamine homologues with potential medical uses would be helping me greatly by directing me towards it, any information sources on novel dimethyltryptamine's would be greatly appreciated!
-eg
---------
Neuropharmacology
Volume 50, Issue 4, March 2006, Pages 412-420
Ellen S. Mitchell, Blair J. Hoplight, Sean P. Lear and John F. Neumaier
Abstract
Inhibition of 5-HT6 receptors has been shown to improve memory consolidation, thus we tested whether a novel tryptamine analog with high affinity for 5-HT6 receptors, BGC20-761 (5-methoxy-2-phenyl-N,N-dimethyltryptamine, PMDT), can enhance long-term memory. BGC20-761 (10 mg/kg i.p.) alone had no effect on social recognition in young rats, however, at doses of 5 mg/kg and 10 mg/kg i.p, BGC20-761 dose-dependently reversed a deficit of social recognition induced by scopolamine (0.4 mg/kg i.p.), an anticholinergic drug that impairs memory. BGC20-761 (10 mg/kg i.p.), scopolamine (0.2 mg/kg i.p.) or BGC20-761 + scopolamine had no effects on novel object discrimination in young rats (2 months). In mature rats (6 months), recognition of the novel object was improved following administration of BGC20-761. Scopolamine had no effect in object recognition. However, the addition of scopolamine disrupted the memory-enhancing effect of BGC20-761. Based on the high affinity of BGC20-761 for 5-HT6 receptors, these cognitive enhancing effects are most likely mediated by 5-HT6 receptor inhibition. The difference in effects of BGC20-761 in young vs. mature rats may reflect the status of memory consolidation in these different age ranges.
We all know about the obvious medical dimethyltryptamine compounds, such as the triptan compounds (zolmatriptan, sumatriptan, etc...) and most have probably read about the potential medical uses of brominated dimethyltryptamine compounds found in some sea invertabrates, but this compound stood out to me, specially in its purported claims to improve memory and brain function.
Anyone with information on this or other dimethyltryptamine homologues with potential medical uses would be helping me greatly by directing me towards it, any information sources on novel dimethyltryptamine's would be greatly appreciated!
-eg
---------
Neuropharmacology
Volume 50, Issue 4, March 2006, Pages 412-420
Ellen S. Mitchell, Blair J. Hoplight, Sean P. Lear and John F. Neumaier
Abstract
Inhibition of 5-HT6 receptors has been shown to improve memory consolidation, thus we tested whether a novel tryptamine analog with high affinity for 5-HT6 receptors, BGC20-761 (5-methoxy-2-phenyl-N,N-dimethyltryptamine, PMDT), can enhance long-term memory. BGC20-761 (10 mg/kg i.p.) alone had no effect on social recognition in young rats, however, at doses of 5 mg/kg and 10 mg/kg i.p, BGC20-761 dose-dependently reversed a deficit of social recognition induced by scopolamine (0.4 mg/kg i.p.), an anticholinergic drug that impairs memory. BGC20-761 (10 mg/kg i.p.), scopolamine (0.2 mg/kg i.p.) or BGC20-761 + scopolamine had no effects on novel object discrimination in young rats (2 months). In mature rats (6 months), recognition of the novel object was improved following administration of BGC20-761. Scopolamine had no effect in object recognition. However, the addition of scopolamine disrupted the memory-enhancing effect of BGC20-761. Based on the high affinity of BGC20-761 for 5-HT6 receptors, these cognitive enhancing effects are most likely mediated by 5-HT6 receptor inhibition. The difference in effects of BGC20-761 in young vs. mature rats may reflect the status of memory consolidation in these different age ranges.
