I havn't tried DMSO on its own, no. Its 99,5% DMSO but I've added some water to it during the extraction process and drank the result with lots of water. Nausea was very low and could have been due to other things. It was definatly euphoric at first and i experienced some kind of body high. A little wobbly but mostly heavy, like mushrooms, but not so jumpy and lightweightish. I think i can't really judge the oil yet with a low dose of 4 drops. Mine is also fabricated in the philipines and says therapeutic grade. It tastes strongly like nutmeg.