while i have no personal experience with Acorus calamus, its worth taking to note that the traditional usage of calamus is that it stimulates the saliva glands, this is of benefit during ceremonies where there is a lot of singing, like singing for 10 hours or more. the mouth can get very dry and tired, one puts a chunk or wad of Acorus calamus root in the corner of the mouth and gum and this is sucked on for hours and allows one to continue singing with out mouth fatigue and dry throut.

Im thinking as the minor stimulation also helps contribute to vocal stamina, it would also stand to reason that the sub-lingual absorption of Acorus calamus's actives might potentate any "medicines" ingested for said ceremonies....

it is also said that Calamus Root can be used in the synthesis of TMA-2, which is most definitely psychoactive....