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Activity of Yopo/Vilca pods

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69ron

Rising Star
SWIM had received some whole "Yopo" pods free from a vendor. He split the pods open and removed 5 very small seeds.

He decided to test the pod alone for activity. He used 500 mg of crushed pods as a quid. He held it for 20 minutes, chewing a little here and there. Chewing released a strong bitter flavor.

Overall the taste was very much like the taste of the seeds (like bitter raw peanuts).

After 20 minutes, the pod material was swallowed.

There was a very light effect felt. A very slight euphoria, like that felt from extremely small doses of bufotenine. 500 mg of seeds is enough for light visual effects orally. But 500 mg of the pod barely did anything at all. The effects felt were too light, and could have been placebo.

Has anyone here on the Nexus experimented with just the pods? They seem to be unpopular with few vendors offering them.
 
Never used them but it sounds kinda interesting...I wonder if the other alks are present in the pods as well..

Might get more conclusive results by smoking some based pod material..
 
At the moment, SWIM feels a very light nausea like that felt from oral bufotenine. SWIM is not sure if its placebo though. It’s very light. But right about now is when it should be felt.

Maybe freebasing with sodium carbonate paste, drying, and then performing a cold acetone extraction followed by room temperature fan evaporation would be good. I think it’s probably a good idea not to use any heat. There may be some heat sensitive compounds like 5-MeO-DMT or DMT present in them.

All of the tests I read show they contain very little alkaloids. But they may have used heat to extract them, or a solvent that’s not good. You never know. I recall some tests showing the seeds contained only DMT and 5-MeO-DMT, but they extracted the seeds using petroleum ether, and so of course that would be the result because bufotenine is insoluble in petroleum ether. Other tests of the same seeds using chloroform showed bufotenine was by far the main alkaloid. So I’m always a little skeptical when there’s not enough test results available.

Does anyone else have any of these pods to test?
 
ok, so swim made an experiment.
he had 16g of pods, so he toasted them for some time in an oven.
then grind them and mixed with 3,5g sodium carbonate. added water and left evaporating.
after it was dried, he added dry acetone and pulled 3 times.
this resulted a yellow powder with strange smell (perhaps freebased mimosa smells similar)
will try it today
 
Druiddream on the ayahuasca forum has tried the pods by themself.

From there http://forums.ayahuasca.com/phpbb/viewtopic.php?t=14920&highlight=yopo+pods:
She does not intend to take nor would she advise any product of the yopo/vilca/cebil tree be taken as tea! Her bioassay was planned as a nasal infusion with MAOI.

GIRLFRIEND IN BRAZIL HAS FIRST RESULTS FROM FIRST BIOASSAY: ACTIVE AND VERY POTENT IN RIDICULOUSLY SMALL AND EVEN DILUTED AMOUNTS.

3.6g phosphoric acid cold water infusion in 300ml water, 1 hour, shaken twice.

To be safe, she decided to forgo any MAOI, but rather underwent just a very weak, partial inhibition from the MAOI-B of a tobacco nasal infusion, whose effects she knows and would not confuse with anything. The tobacco infusion has no overt effects at such small amounts, except for relief from fatigue.

She then insufflated 1/2tsp (1/8 tsp. at a time) of the 300ml cold water pod infusion and despite the tobacco having waken her up, within a few minutes, she was hit with a wave of relaxation and sedation, becoming quite tired again and lay down on the sofa, eyes covered in a blindfold, and she lay still, meditating.

Whatever is in the pods is INCREDIBLY potent and active without caapi or rue IN TINY AMOUNTS. Whatever it is, she says, has an unmistakable tryptamine-family signature, and clearly totally distinct from the bufotenine effects of seed. But in addition, it was more "transparent" than the inception of the light or forest friends, without any transitional "alert". Instead, it was immediately and suddenly very sedating, comfy and *highly* euphoric, producing intense pleasurable body waves, and, to be quite frank, was highly stimulating to the root chakra (downright libidinous!). It made her yawn as with the light or forest friends, but because there was no "alert", it could easily have been mistaken for a regular yawn. This was followed by a deep 15-minute hypnogogic trance in an enhanced black space with some reddish tinges and with intense body feelings and emotions. The black space had a structure and was not uniform as in unaided meditation.

After the 15-minute deep trance, she got up still altered just at a threshold level but still had strong body feelings that were similar to the shamanic feel of the light, and colors were very bright and intense when she opened her eyes! She said it made her growl and moan, and it was hard to lie still, and even just standing still is somehow confining after the trance is over.

Heartrate was elevated, as she recalls from cannabis from years ago, she said, and she reported a *very* slight tightness in the neck as with the seeds, but without any of the other unmistakably distinctive feelings of the seed in the thighs, calves, and head, which sets them apart from other forms of the molecule. After the sedative phase, it lightened up into a highly euphoric, excited state full of bright energy and motivation, but she says she didn't want to be too active because of the sense of strain from the elevated heart rate. She also says that if an MAOI were to raise this heartrate even higher, she would probably start to feel uncomfortable and unsafe, but at this level with no MAOI, it was pleasantly invigorating, she says, comparable to the heartrate of the Morning Glory. The excitement at one point made her slightly nauseated, but not in a sick way.

One hour later, she says her heartrate is still slightly elevated, mood is happy, energy is high, euphoric *giggly* feeling, like being tickled from the inside out is also apparent, AND a very slight HEADACHY feeling, just on the verge. This could be a hypertensive reaction from having had guarana in the morning before the experiments began OR from the tobacco infusion, and it would be wise to AVOID CAFFEINE AND TOBACCO with the pods as well.

Quite honestly, she does not know what these pods contain, but WHATEVER IT IS, IT IS ACTIVE IN MINISCULE AMOUNTS AND IS EXTREMELY POTENT.

Her best guess is that it must be rich in something like 5meo (???) , and that IT SHOULD NOT BE USED WITH AN MAOI, at least that seems unwise so far because of the already high heartrate, and it SHOULD NOT BE INGESTED AS TEA.

CAUTION IS WARRANTED. WE DON'T KNOW WHAT THIS IS, but whatever it is, it was not toxic either when smoked (little effect) or insufflated as nasal infusion, and was actually very stimulating and enjoyable. Whether it can be worked with shamanically for lesson-acceptance remains to be seen, although my girlfriend says she does not feel called to go deeper with them because of the intense effect on cardiac functioning.

In summary, my girlfriend feels that the seeds are much gentler (when taken in a comparable fashion and concentration) and the teaching and visionary power are far more pronounced with the seeds.
Questions which have arisen from the bioassay:

----> Does anyone recognize this as 5meo from what you have read or studied?

---> The dosage for this is RIDICULOUSLY tiny! Much less than for a yopo seed nasal infusion by far!
 
Well SWIM tried a larger sublingual dose of 1 gram of empty pods ground into powder and mixed it with 60 mg of calcium hydroxide. He felt mild effects identical to that of sublingual DMT. It was very mild. He felt that typical freebase DMT burning sensation coupled with the burning from the calcium hydroxide. The calcium hydroxide used was definitely too much. His mouth was sore from it for several hours following.

It's not very pleasant having it in the mouth. SWIM says there's something in the pod that makes your mouth feel pretty crappy. I think maybe there's a lot of tannins present?

There was no noticeable bufotenine effects felt. No noticeable 5-MeO-DMT effects felt either. Potency wise, it was roughly equivalent to maybe 250 mg of Virola calophylla resin. SWIM is not totally sure though. The effects were pretty weak.
 
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