Yopo effects are quite strong on the body. Sweating, high heart rate, tremors.

Best way woud just be to prepare the snuff with CaOH. Which can be easily made by burning crushed sea shells or other sources of limestone over 900°C.

Then add water to the CaO to make CaOH. Or just use NaOH or KOH. NaHCO3 or NaCO3 do not work as well. Bufotenine needs more basic conditions.

Then prepeare the snuff and add it to your changa. Make sure the snuff is dry before you try to take it.

You could also just use the seeds as is or crushed. Make sure to roast them in their shell to drive the water out of them.