pitubo raises some good points, and that link he posted is good stuff

I'll add a bit of a caveat; if things end up working to their fullest extent, given all the factors, if it all goes off without a hitch ..your friend may be biting off more than they can chew, ..but then again since they've drank before then I think all will be well in the end most likely, then again this is just my opinion. Relaxed and loose

Tbh, the few brews that i've drank, primarily vine and chacruna, also vine and mimosa, man ...they were incredibly more difficult than pharmahuasca, the experience/s that I've had with pharmahuasca were incredibly concise and crisp, highly detailed, and gentler in a sense, even when things took a dive off the deep end, there was still this modicum of sense of self left always, though there were numerous times with drinking brews, for me it's different, much much more somatic, bordering on incredibly physical pressures, vibrations, feelings, idk ..it's always felt stronger overall relative to the pharma experience/s. These are just my opinions/experiences though.

I still think things will be alright ..given the bit of context of the situation from what you'd wrote, having drank before, etc ..that already gives some good footing for this upcoming experience imho, versus not having drank at all before.

Even say if you were cut it down a bit - to dose 200mg harmine freebase, wait 25 minutes or until you felt the harmalas set in, then maybe take 60mg dmt, wait an hour from that point and assess the momentum of what's happening, maybe have a small booster set aside [both harmalas and dmt mixed], have it all calculated out beforehand - just to make sure you're not going too far overboard. Otherwise it could be an incredibly long long night :twisted:

Maybe like 25-30mg dmt mixed with 50mg more harmalas' - that's if nothing much is happening within that 90 or so minute-timeframe, aside from the harmala effects [which should be present].