entheogenic-gnosis
Rising Star
Marijuana's active constituents contain no nitrogen and thus are not alkaloids, the cannabinoids produced by the marijuana plant are terpenoid hydrocarbons.
Yet alkaloids have been identified and do exist in cannabis plants...
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The first Cannabis alkaloid to be fully identified was cannabisativine which was isolated in Mississippi in 1975 from the roots of a Mexican variant (Lotter et al., 1975). TLC indicated the presence of this substance in the leaves of the plant as well. "
Article: Historical overview of chemical research on cannabinoids
·Raphael Mechoulam
·L Hanus
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So it caught my attention when I read of "anhydrocannabisativine" an alkaloid produced by a variant of the cannabis sativa plant.
Cannabimine A, may be identical to anhydrocannabisativine, which shares the same molecular formula (-bottom of page)
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Abstract
Ethanol extracts of the leaves and roots of a Mexican variant of Cannabis sativa L. (marijuana) afforded, after partitioning and chromatography, the new spermidine alkaloid, anhydrocannabisativine. The structure was determined by spectral analysis and semisynthesis.
www.ncbi.nlm.nih.gov
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Though further information regarding anhydrocannabisativine is sparse...
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For many years during the 19th century the possible presence of alkaloids was discussed. Preobrajensky (1876) claimed the presence of nicotine in Cannabis sativa resin but this was refuted by Kennedy (1886). Hay (1883) was able to obtain an alkaloid, tetanocannabin, which pos-sessed strychnine like properties when tested on a frog. Although the balance of evidence was in favor of some alkaloidal substance (in addition tocholine and trigonellin) being present in small quantity in Indian hemp, almost no further work along these lines was undertaken.This lack of data apparently did not prevent the marketing of ‘Cannabine Alkaloid Merck’ (MerckIndex, 1896), as ‘fine needles ... hypnotic without dangerous secondary effects’.The first solid indication of the presence of alkaloids in Cannabis, in addition to the above-described simple nitrogenous bases, was put for-ward much later in Klein et al. (1971). Alkaloidal mixtures were extracted from plant material. The total crude yield was 0.02%. Four alkaloids, named cannabimines A – D, were isolated bypreparative TLC. High-resolution mass spectro-metric data indicated molecular weights of 279 –363. Structural assignments could not be made.No further work on these alkaloids has been reported. Cannabimine A, C21H37N3O2 may be identical to anhydrocannabisativine, which sharesthe same molecular formula.The firstCannabisalkaloid to be fully identifiedwas cannabisativine which was isolated in Missis-sippi in 1975 from the roots of a Mexican variant(Lotter et al., 1975). TLC indicated the presenceof this substance in the leaves of the plant as well.The structure of cannabisativine was elucidatedby X-ray crystallography. A second alkaloid,named anhydrocannabisativine, was isolated in aminiscule yield by the same group from the leavesand roots of a Mexican variant ofCannabis sati6a(ElSohly and Turner, 1976). Anhydrocannabis-tivine has been found in plant samples ofCan-nabisfrom 15 different geographical locations.Several related spermidine alkaloids palustrineand palustridine (both found inEquisetumspe-cies) are known in nature.While the crude alkaloidal mixture caused de-creased activity in mice, in view of the low con-centration of the alkaloids in the plant, it isdoubtful whether these components are relevant to Cannabis activity in man. For a detailed reviewof cannabinoid alkaloids see Mechoulam (1988 )
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-eg
Yet alkaloids have been identified and do exist in cannabis plants...
-----
The first Cannabis alkaloid to be fully identified was cannabisativine which was isolated in Mississippi in 1975 from the roots of a Mexican variant (Lotter et al., 1975). TLC indicated the presence of this substance in the leaves of the plant as well. "
Article: Historical overview of chemical research on cannabinoids
·Raphael Mechoulam
·L Hanus
------
So it caught my attention when I read of "anhydrocannabisativine" an alkaloid produced by a variant of the cannabis sativa plant.
Cannabimine A, may be identical to anhydrocannabisativine, which shares the same molecular formula (-bottom of page)
-------
Abstract
Ethanol extracts of the leaves and roots of a Mexican variant of Cannabis sativa L. (marijuana) afforded, after partitioning and chromatography, the new spermidine alkaloid, anhydrocannabisativine. The structure was determined by spectral analysis and semisynthesis.
Anhydrocannabisativine, a new alkaloid from Cannabis sativa L - PubMed
Ethanol extracts of the leaves and roots of a Mexican variant of Cannabis sativa L. (marijuana) afforded, after partitioning and chromatography, the new spermidine alkaloid, anhydrocannabisativine. The structure was determined by spectral analysis and semisynthesis.
www.ncbi.nlm.nih.gov
------
Though further information regarding anhydrocannabisativine is sparse...
----
For many years during the 19th century the possible presence of alkaloids was discussed. Preobrajensky (1876) claimed the presence of nicotine in Cannabis sativa resin but this was refuted by Kennedy (1886). Hay (1883) was able to obtain an alkaloid, tetanocannabin, which pos-sessed strychnine like properties when tested on a frog. Although the balance of evidence was in favor of some alkaloidal substance (in addition tocholine and trigonellin) being present in small quantity in Indian hemp, almost no further work along these lines was undertaken.This lack of data apparently did not prevent the marketing of ‘Cannabine Alkaloid Merck’ (MerckIndex, 1896), as ‘fine needles ... hypnotic without dangerous secondary effects’.The first solid indication of the presence of alkaloids in Cannabis, in addition to the above-described simple nitrogenous bases, was put for-ward much later in Klein et al. (1971). Alkaloidal mixtures were extracted from plant material. The total crude yield was 0.02%. Four alkaloids, named cannabimines A – D, were isolated bypreparative TLC. High-resolution mass spectro-metric data indicated molecular weights of 279 –363. Structural assignments could not be made.No further work on these alkaloids has been reported. Cannabimine A, C21H37N3O2 may be identical to anhydrocannabisativine, which sharesthe same molecular formula.The firstCannabisalkaloid to be fully identifiedwas cannabisativine which was isolated in Missis-sippi in 1975 from the roots of a Mexican variant(Lotter et al., 1975). TLC indicated the presenceof this substance in the leaves of the plant as well.The structure of cannabisativine was elucidatedby X-ray crystallography. A second alkaloid,named anhydrocannabisativine, was isolated in aminiscule yield by the same group from the leavesand roots of a Mexican variant ofCannabis sati6a(ElSohly and Turner, 1976). Anhydrocannabis-tivine has been found in plant samples ofCan-nabisfrom 15 different geographical locations.Several related spermidine alkaloids palustrineand palustridine (both found inEquisetumspe-cies) are known in nature.While the crude alkaloidal mixture caused de-creased activity in mice, in view of the low con-centration of the alkaloids in the plant, it isdoubtful whether these components are relevant to Cannabis activity in man. For a detailed reviewof cannabinoid alkaloids see Mechoulam (1988 )
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-eg