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*Not a doctor* I am bipolar 1 and have been vaping DMT almost daily sometimes twice a day for a few months now. have yet to fully breakthrough as i understand it to be and read about peoples experience. I was taking Abilify, Remeron, Lamotragine, Adderal and Clonazapem. i slowly stoped getting much result at all at doses of up to 200mg of quality spice. i originally achieved strong visuals and the ear ringing etc going in for about a month or so now if i do get anything its skips all this and i'm imagining sub breaktrhoughs sneak up on me. I've read a lot of quality studies from institues of health, reputable journals and universitys. on SSRI's or SNRI's you need to be carefull of seratonin syndrome. Abilfiy and Remeron and strraight antidepressants are 5HT2a and 21 to a point seratonin antagonists that keep the receptors for these uptaking serotonin where NN floods us with Seratonin. two things here - risk of seratonin syndrome (i was getting bad headaches sometimes so think i had a smidge of this) and slowly stopped reacting to the NN. NN works predominantly with the 5HT2a receptors as an agonist (takes serotonin in) where antidepressants and antiphysocotics are antagonists (keeps your receptors from taking up 5HT2a so you have more in your brain which is what shows the efficacy for fighting depression. I stopped taking abilify and remeron and had two sub breakthroughs again but no entry visuals or sound affects. NN also effects Glutamate receptors and my Lamotragine is a mild antagonist of this. i'm thinking the meds were getting in the way so i decided to experiment without abilify and remeron. I am getting very nautious for a while now and almost vomiting but not sure what this is a funtion of. i have started to speak to the molecule setting intentions showing gratitude etc while premeditating as i've read peoples experiences are helped by this. Again not a doctor but these are from indepth reading and personal experience as mentione. MDMA can be very dangerous for seratonin syndrome as well and ampetamines and benzopiazanes don't help the cause either. safe tripping and hope we both get what we are searching for.