I take antidepressant sometimes for my chronicle nerves pains in the feet but i quit for at least a week before having  mushrooms !

Anytime i had psilocybin while taking Duloxetine , it was at least 5 times less potent than without ! A real pity

I think it depends on ppl but it's known that mixing serotonin boosters isn't good anyway ...

it can even lead to "serotonin syndrome" which could even be deadly in rare cases , so they say ...