I take an SSRI, and even with rather high doses DMT (up to 60 mg vaporized/smoked, 150mg ingested with 150mg harmalas) I can only get to the 'fractal overlay' phase with ease, and the 'total fractal experience' very few and short times... So I have decided to wait till I am off of the SSRI in a few months, and then even wait some more (6 weeks) so my receptors in my brain are all squeaky clean. Only then will I try again.