what he's not mentioning is that it's not sustainable in future generations. progeny revert back to wild-type genetics.

it's similar to what has been observed with mutated strains of claviceps spp.

the same is true for mushrooms. each generation has to be treated with precursors, or genetic modification...yes, the nmt->dmt->baeocystin step is spontaneous and irreversible, so manipulating DMT production isn't the issue. Dope 'em with NMT or tryptamine.

as far as feeding them melatonin, I don't think the sterics of the end product would elicit any central activity.