Members of the previous forum can retrieve their temporary password here, (login and check your PM).

Reply to thread

Message

4,5-MDO-N-alkyltryptamines appear to hold more promise than 4-OH-5-MeO-N-alkyltryptamines, especially if one looks at the parallels in the phenylethylamine world But that becomes a different ball game unless one finds the enzyme and/or corresponding gene for the reverse of the MDO- ring-opening reaction that occurs in various metabolic systems.

Clearly, numerous plants are capable of forming benzodioxole ring systems and AFAIK this is usually from a methoxy group adjacent to a hydroxy group. Whether this would work for indoles ultimately depends on the enzyme(s) concerned.

What examples of 4,5-MDO- and 4-OH, 5-MeO-tryptamines are there in the plant world?

Apologies here for a bit of an off-the-top-of-the-head ramble!

<blockquote data-quote="downwardsfromzero" data-source="post: 3445253" data-attributes="member: 1025">4,5-MDO-N-alkyltryptamines appear to hold more promise than 4-OH-5-MeO-N-alkyltryptamines, especially if one looks at the parallels in the phenylethylamine world <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite2" alt=";)" title="Wink&nbsp; &nbsp; ;)" loading="lazy" data-shortname=";)" /> But that becomes a different ball game unless one finds the enzyme and/or corresponding gene for the reverse of the MDO- ring-opening reaction that occurs in various metabolic systems.Clearly, numerous plants are capable of forming benzodioxole ring systems and AFAIK this is usually from a methoxy group adjacent to a hydroxy group. Whether this would work for indoles ultimately depends on the enzyme(s) concerned.What examples of 4,5-MDO- and 4-OH, 5-MeO-tryptamines are there in the plant world?Apologies here for a bit of an off-the-top-of-the-head ramble!</blockquote>

[QUOTE="downwardsfromzero, post: 3445253, member: 1025"] 4,5-MDO-N-alkyltryptamines appear to hold more promise than 4-OH-5-MeO-N-alkyltryptamines, especially if one looks at the parallels in the phenylethylamine world ;) But that becomes a different ball game [i]unless[/i] one finds the enzyme and/or corresponding gene for the reverse of the MDO- ring-opening reaction that occurs in various metabolic systems. Clearly, numerous plants are capable of forming benzodioxole ring systems and AFAIK this is usually from a methoxy group adjacent to a hydroxy group. Whether this would work for indoles ultimately depends on the enzyme(s) concerned. What examples of 4,5-MDO- and 4-OH, 5-MeO-tryptamines are there in the plant world? Apologies here for a bit of an off-the-top-of-the-head ramble! [/QUOTE]