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Thank you very much Mindlusion for bringing up that important point.


In fact I was thinking about utilising formaldehyde (Eschweiler-clark) as methylating agent in my last step. I assume the formation of reactive Schiff-base leads to an opportunity for side reactions to take place and create harmful side products.


Then again I'm thinking of utilising the Gabriel synthesis might be a way around the problem I face and have to change some other steps. Then again I don't want to talk much about this as then more harmful chemicals/procedures will be necessary.


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