Nice find, ik add it here as pdf. Interesting to see LSD did not produce any observed cardio toxic effects in mice.
Summary from paper:
Microdosing, the prolonged ingestion of psyche-
delics at subhallucinogenic doses, has gained popularity for its
perceived cognitive and emotional benefits. Psychedelics have high
affinity for 5-HT2B receptors, a receptor known to cause human
heart disease with strong chronic activation. We investigated the
effects of microdosed psychedelics on cardiovascular health in mice
using echocardiography after chronically administering either
serotonin or d-fenfluramine as positive controls or lysergic acid
diethylamide (LSD) at two subhallucinogenic doses. Serotonin
produced significant ventricular thickening at 4- and 8-weeks, and
d-fenfluramine caused aortic valve regurgitation at 4-weeks. No
significant changes were observed in any vehicle or LSD group. We determined the affinity and potency of LSD, psilocybin, and
norfenfluramine at mouse and human 5-HT2BRs and observed no significant differences. We calculated that levels of 5-HT2B
activation by low-dose LSD were substantial, but short-lived, compared to the cardiotoxin d-fenfluramine. Together, these data
provide no evidence of ventricular or valvular remodeling associated with prolonged administration of low-dose LSD in mice.
