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noagain, an acid only acts as a catalyst. it's represented in the reaction as H+;and the reaction isn't specific to acid-catalyzed addition either; mass spec determinations of thermolytic decarboxylation of tryptophan product, using ketone catalysts with no acid involved, have also shown the production of beta-carbolines. this reaction is driven by heat (~ >165C), and the quaternary ammonium intermediate is so susceptible to oxidation that the ketone will be added to the cyclized product, depending on the ketone used.
no
again, an acid only acts as a catalyst. it's represented in the reaction as H+;
and the reaction isn't specific to acid-catalyzed addition either; mass spec determinations of thermolytic decarboxylation of tryptophan product, using ketone catalysts with no acid involved, have also shown the production of beta-carbolines. this reaction is driven by heat (~ >165C), and the quaternary ammonium intermediate is so susceptible to oxidation that the ketone will be added to the cyclized product, depending on the ketone used.