Not all Virola is the same. Virola theiodora contains mostly 5-MeO-DMT and Virola calophylla contains mostly DMT. They are two very different experiences but usage is essentially the same. Although 6% calcium hydroxide by weight is needed for Virola calophylla to work properly, while Virola theiodora works fine without it.

With Virola calophylla, 500 mg of resin (plus 30 mg of calcium hydroxide) taken sublingually or snuffed is enough for light visual effect. 500 mg of either resin does not approach anything near a breakthrough experience. It’s a mild dose.

I don’t know what amount is needed for a DMT style breakthrough experience with Virola calophylla, but I know it’s possible because shamans do that all the time. They use several grams at a time.