They work very well for that. SWIM used 3 seeds with 75 mg of mescaline and found that they very effectively blocked the stimulant effects of mescaline. At 75 mg, for SWIM, mescaline is mostly just a stimulant and euphoriant, with very mild psychedelic effects that are hardly noticeable. 3 D. inoxia seeds made the trip very smooth and relaxed without effecting the psychedelic or euphoric elements of the mescaline. SWIM has not tried large doses of mescaline with them yet.