Some shamans mix small amounts of Datara and similar plants into their ayahuasca brews, and the mix is not known to be dangerous as far as I am aware. It’s known to be much more potent though. I think D. stramonium would work better than D. inoxia. SWIM has found D. stramonium to potentiate every psychedelic he’s tried with it, but he hasn’t found D. inoxia to do that. But maybe the dose of D. inoxia was just too small to work.

3 Datura inoxia seeds very effectively reduce anxiety. The main ingredient, scopolamine (97% of the alkaloid mix in the seeds) is said to increase the effectiveness of other tranquilizers. SWIM has not mixed it with any other tranquilizers yet. He has kava. That’s an interesting test. I have never heard of dangerous interactions when using microdoses of scopolamine with other drugs. 4 seeds contain about 176 micrograms and an average dose of scopolamine used to treat sea sickness is 400-800 micrograms. So I think that’s a safe dose to play around with. But I would start with 1 seed first, just to be extra cautious.