Yes, but remember I’m talking specifically about the seeds. Alkaloid content is not the same in the rest of the plant.

Datura stramonium seeds contain up to 0.7% tropane alkaloids with 80% being hyoscyamine which is a stimulant at low doses. Datura inoxia seeds contain up to 0.4% tropane alkaloids with 97% being scopolamine which is a sedative at low doses.

They have very different effects. You can tell them apart blind folded for sure with ease.

I know very little about Datura metel.