My friend tried Datura for the first time last night. Not knowing what to expect he ate just one Inoxia seed. About 3 or 4 minutes in he had an overwhelming adrenaline rush followed by a short 15 second feeling of fear. He was fine after that and felt quite nice. He woke up a few times throughout the night with the pins and needle "dead arm" feeling. Not sure if it was related. He did remember his dreams very thoroughly.

What I find odd is the adrenaline followed by fear. He didn't read this thread until today so it was not power of suggestion. He is going to stick with 1 a few more times before he bumps it up. He has an irrational fear that his seeds are stronger than the norm. 

EDIT: I should note he took 3mg of Melatonin 30 minutes prior.