Whether Sativa, Indica, Ruderalis, male, female, hermaphrodite, wild, bred for fiber, seeds or medicinal resin - Cannabis is the best source for the anti-tumor activities of D9THC, D8THC, CBD, CBG, CBC, D9THC-a, CBD-a, CBN and terpenes. The medicinal potential of Cannabis is focused in the mature fan Leaf, where the Cannabinoid content has peaked after the Leaf has fully developed it's structure and the whole colas before trichomes become cloudy. Between 70 and 90 days, and sooner for Ruderalis strains is generally the time when Cannabinoids have begun to peak. Because of the sequential appearance of Cannabinoids, some people's conditions respond better to younger Cannabis, such as halfway through maturity.
"The Hemp plant is actually an excellent plant because the THC content can be low, that's if you're treating a condition for which appears CBD food supplement is in order.
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The plants we're using in Luxembourg have only 1% CBD, a 1% CBD plant is providing you with 19 times more CBD per pound than Oranges provide you of vitamin C. A 1% is an excellent source, you can make tremendous concentrates you can eat the plant raw - and the absence of the THC - you can heat Hemp, which you can't do with other strains because the THC acid comes out and you end up with a psycho-toxic substance."
"The use of the raw plant includes the acid cannabinoids; CBDA, THCA, CBGA, CBCA. The acid cannabinoids, CBDA and CBGA are now known to act at GPR55 as potent antagonists of that pro-inflammatory receptor. The acid cannabinoids are 2-4 fold more effective than the neutral cannabinoids, which have been the exclusive focus of study for the last 30 years. The neutral cannabinoids, CBD, THC, CBG, CBC … are functionally synthetic molecules made by application of heat to alter the naturally occurring Acidic Phytocannabinoids. The specific ratio of cannabinoids is an area of tremendous significance and an area in need of additional research. Consumption of the whole mature raw flower / bud and leaf is the best current thought. The amount per day is dependent upon the weight-to-weight cannabinoid content analysis of that specific plant as there is dramatic variation between particular plants of the same name and across time for a specific plant.
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If analysis is not available, assume high THC concentration in the 8% to 21% weight to weight or w/w. In general CBD is usually less than 1% w/w. Another way of describing the relative amounts of THC to CBD is cannabinoid content. For the vast majority of strains in California the ratio OF CBD TO THC per 100 grams of cannabinoid, is 0.4 to 1.0 grams of CBD/100gm to 90-95 grams of THC/100gm. Sadly the other 78 cannabinoids share the remaining 4 grams. Note that W/W is the amount of CBD per unit weight of cannabis where cannabinoid content is an estimate of the relative amount of THC, CBD, CBC, CBG, CBN etc per 100 gm of cannabinoid extracted from a particular strain."
Replace high THC plants with plants of increased CBD content and ideally with plants providing specific ratios of CBDA to THCA indicated for the specific medical condition.
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The THC dose, for those that are comfortable with THC, is 10-15 mg. If you are blending a mature bud into a glass of juice it could and should have 5-600 mg of THCA and 5-600 mg of CBDA if the plant is a 1:1 plant such as the original Cannatonic 6.9%w/w CBD to 6.2% w/w THC or a tested strain of Harlequin, which range from 4%/4% to 8%/8% CBD/THC. If that juice is accidentally heated by placing the ‘vegetable’ juice into a vegetable soup, it will create a very psychotoxic dose of THC.
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Reiterating to a fault, if you are consuming 600 mg of a 1:1 plant, you are consuming not only 600 mg of CBDA but also 600mg of THCA, upon heating the THCA turns in to approximately 580mg of THC when the tolerable dose is 10 mg! That would be like consuming 58 brownies when you can only tolerate 1!
If you find a source of cannatonic seeds beware that the cannatonic feminized seeds can vary widely from the original plant. Recent HPLC testing showed an expression of CBDA from 22% w/w to <1%CBDA and concurrently THCA contents ranged from 1% w/w to 30 % w/w."
William l. Courtney, M.D.