DMT Nasal Spray

[AllergyMeds]

As you may know, people have attempted to snort DMT, specifically the fumarate version since it burns less on the nose compared to the freebase one, however, this isn’t very successful since most people have reported snorting up to 100mg to feel around 10mg of effects. I was browsing the salvia subreddit (another psychodelic which requires similar special ways of ingestion, an example of this being that it’s normally orally inactive and is commonly mostly only smoked) and I found a post which describes extracting the Salvinorin A and putting it into nasal spray using a cyclodextrin called HPBCD

Cyclodextrins are drug delivery chemicals synthesized from starch by special enzymes. They are cheap to buy, and can be bought on the normal internet/surfaceweb. Is a nasal spray possible with DMT fumarate and HPBCD? Here is the link to the Salvinorin A nasal spray recipe and its corresponding reddit post:

Recipe: tinyurl dot com/SpraySpray1

Post: tinyurl dot com/SpraySprayRP

There’s another form of DMT called DMT hemifumarate, it’s less hydroscopic so it probably wouldn’t work as well for this hypothetical nasal spray, but I thought I would bring it up because I remember seeing it on a .gov site for IV DMT human trials and it just randomly came up in my brain.

 

[Global_Roaming]

I wonder if DMT benzoate would be a viable candidate for a HPBCD nasal spray?

 

[Transform]

Hi, welcome.

Here is the pdf on salvinorin extraction and complexation, attached below.

What is the stoichiometry of the "hemifumarate"? We're quite well-versed with DMT fumarate here, so I'd make an educated guess that the term refers to the 2:1 DMT fumarate, which could be regarded as the normal fumarate, as opposed to DMT hydrogenfumarate, the 1:1 fumarate, which could also be referred to as the "bifumarate", in analogy to other 1:1 salts of a monovalent base with a dibasic acid.

I don't know if you're familiar with handling DMT fumarate, but the crystalline form can be quite hygroscopic. If the 2:1 salt is less hygroscopic than the 1:1 one, surely that would be an advantage? Absorbing moisture from the air causes the material to become sticky, as well as reducing the apparent potency by diluting the material - something which could lead to troublesome errors in dosing further down the line.

Or were you conflating hygroscopic with hydrophilic, a somewhat different term?
So, yeah, intranasal DMT does sort of work but is unpromising dosage-wise. You'd need to have a good reason for fiddling around with HPBCD just on the off-chance that it might make intranasal worthwhile somehow, so I'd be inclined to suggest that better ROAs do exist, while acknowledging that vaporisation, nebulisation,smoking and/or MAOI-activated oral dosing might not be suitable for everyone.

One should also be aware of the possibility of auditory neurotoxicity that has been seen with high doses of HPBCD.

 

[-AllergyMeds]

I don't know if you're familiar with handling DMT fumarate, but the crystalline form can be quite hygroscopic. If the 2:1 salt is less hygroscopic than the 1:1 one, surely that would be an advantage?

Wait, you’re right, DMT hemifumerate would be better for this hypothetical since it is less hygroscopic.
In fact, I found another .gov research paper which describes DMT hemifumarate being used in a nasal spray human trial test which uses table salt:
“DMT hemifumarate was aseptically dissolved in NaCl 0.9% to form a nasal spray solution with a 5 mg DMT hemifumarate concentration per puff”

What is the stoichiometry of the "hemifumarate"?

I do not know since I’m not much of a chemist, I must admit; I found it when I was searching for an ultra pure synthetic lab made version of DMT, (was paranoid about what was going in my lungs) and I found it on a .gov site’s research paper, as read here:
“The DMT hemifumarate was minimally 99.9% pure, with no significant impurities or residual solvents, thus meeting regulatory standards for administration to humans”
The other research paper which mentions the hemifumerate nasal spray as I stated earlier says it was extracted from mimosa tenuiflora albeit less pure (98.9%) than the synthetic one from the 2nd paper I mentioned
Here are links to both of the government research papers:

Paper 1 with nasal spray and mimosa extraction: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10711279

Paper 2 with ultra pure DMT synthesis:
https://pubmed.ncbi.nlm.nih.gov/32608093

One should also be aware of the possibility of auditory neurotoxicity that has been seen with high doses of HPBCD.

Thank you for bringing this up, for I did not know this
I wonder if DMSO or another delivery agent would be better, I found a research paper on springer which uses DMSO instead of a cyclodextrin for the nasal administration of Salvinorin A
I do also wonder if the DMT nasal spray would benefit from like a 1/4 teaspoon of olive oil as a lubricant

Another thing I wanted to mention is that a lot of times improper nasal administration can decrease the potency of a drug, like a lot, similar to improper smoking. I watched a video on how to take properly self-administer allergy nasal spray medication and after that my allergies completely vanished, you can see proper nasal spray administration here:

If this DMT nasal spray was to be made, a sticker which has a silhouettes of the visuals you see at the 1:40 and 1:52 timestamps of the video above would be helpful, and printed instructions on the sticker too which say something like tilt head slightly forward, don’t inhale or if you must inhale very lightly, administer as shown in the image above to allow substance to absorb into nasal cavity to bloodstream, stuff like that, and also translated into chinese and spanish too because why not


- Irrelevant to DMT -
I was also looking at an article which says Stanford scientists bioengineered yeast to yield morphine, so people around the world (they mostly had india in mind though) could have grown-your-own-just-add-sugar painkiller yeast kits, which I thought was pretty epic, I left them a voicemail saying they should look into growing Salvinorin A out of the yeast since it is also an opioid and is way more potent than morphine, and since it is a kappa-opioid, people would need to take less and less each time because kappa-opioids like salvinorins have “reverse tolerance”
I do wonder if other natural substances could be yielded from this yeast, would take the power from cartels and democratize cocaine usage, at least, that’s what the article I read says, (article writer probably just wants free coke lol) in reality though, I’m guessing the yeast only yields opioids and terpenoids for now

 

[-AllergyMeds]

I wonder if DMT benzoate would be a viable candidate for a HPBCD nasal spray?

This is a form of DMT that’s new to me, after doing a quick google search, benzoates are used for allergy inhalers
I wonder if that would translate to nasal membranes or could be used for a DMT inhaler as long as the other ingredients included in an inhaler are there (buffering agents, propellants, etc.)

 

[fractals4life]

This is a form of DMT that’s new to me, after doing a quick google search, benzoates are used for allergy inhalers
I wonder if that would translate to nasal membranes or could be used for a DMT inhaler as long as the other ingredients included in an inhaler are there (buffering agents, propellants, etc.)

here's a good catch up on DMT Benzoate, easy to make! TEK - The benzoic acid tek