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Dosing via microparticles to shield from maoi in the stomach?

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DreaMTripper

DreaMTripper

Rising Star
What it be possible to bypass maoi in the stomach by using pcl microparticles?
Collagen-coated polycaprolactone microparticles as a controlled drug delivery system - PubMed

Microparticle - Wikipedia

[q] The mechanism of drug release from microspheres can occur in the following ways:[4]

Diffusion: On contact with aqueous fluids in the gastrointestinal tract (GIT), water diffuses into the interior of the particle. Drug dissolution occurs and the drug solutions diffuse across the release coat to the exterior.

Erosion: Some coatings can be designed to erode gradually with time, thereby releasing the drug contained within the particle.

Osmosis: In allowing water to enter under the right circumstances, an osmotic pressure can be built up within the interior of the particle. The drug is forced out of the particle[/q]
 
IF I'm understanding this technology, I don't think this would work. Unfortunately.

Firstly, the stomach has plenty of "aqueous fluid", so if that's what causes the particles to split, then they will break down (or at least start to) in the stomach and release their goodies. Next, even if they managed to make it through the stomach intact, I'm pretty sure that the small intestine is swimming in MAO, so that's not a good place to release your DMT either. Now as DMT enemas apparently work without MAOI, I'm gonna assume that the lower intestine is relatively MAO-free. So if the particles had some kind of coating which protected the contents until they reached the LI (and I had an idea that they do make ones like this for certain medications, could be wrong about that though), then this might work? You would still need to get the drug into coated particles somehow though- and I'm not sure whether this is the kind of thing that could be done at a "kitchen-chemistry" level. Then again, if it was feasible I'm sure there would be alot of people interested in making it happen!

I would be very interested to know what some more competent biochemists think, as I'm intrigued by this possibility, so I really hope that I'm wrong!
 
Looks like those enteric coatings I was thinking of are actually designed to break down in the small intestine, so they wouldn't work for this.
 
Ok yes, maybe too many MAOI 'blockades' to pass..however if one can be designed using the 'erosion' release mechanism then it may be able to get as far as the blood stream and break down there?
Dosing for a visionary experience would probably need a very large dose to achieve effects but I was thinking more along the lines of therapetic doses.
I agree most probably way beyond the kitchen chemist , until 3D printers take off anyway, but would be interesting to know if it would work with alkaloids in theory.
 
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