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From chat gpt.


A typical breakthrough dose of smoked DMT (freebase) is generally considered to be around 20-50 mg. The exact amount can vary depending on factors such as individual tolerance, lung capacity, and the method of vaporization.


Low dose (10-20 mg): Produces mild effects, with visual distortions and euphoria, but usually not a full breakthrough.


Moderate dose (20-30 mg): Stronger visual and sensory effects, with some possibility of a breakthrough experience.


Breakthrough dose (30-50 mg): Full dissociation from reality, with intense visuals and the sensation of entering another realm or encountering entities, which is often described as the "breakthrough" experience.


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For oral consumption, the dosage range is typically:


DMT (orally, with MAOI):


Low dose: 30-50 mg


Moderate dose: 50-100 mg


High dose (breakthrough experience): 100-150 mg or more



MAOI dosage:


You’ll also need to consume an MAOI (such as Banisteriopsis caapi vine or synthetic harmala alkaloids like harmine or harmaline) to inhibit the breakdown of DMT in the gut. A typical dose of MAOIs in ayahuasca brews is around 50-200 mg of harmala alkaloids, depending on the source.



When combined, the effects last longer than smoked DMT (typically 4-6 hours or more), and a breakthrough can occur with doses in the higher range (100-150 mg). It's essential to be cautious with MAOIs as they can interact with certain foods and medications, leading to potential side effects.


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