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Exposure to β-carbolines norharman and harman

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InMotion

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Exposure to β-carbolines norharman and harman
W Pfaua,
K Skogb

a Umweltmedizin Hamburg e.V. and Institute of Experimental and Clinical Toxicology, Hamburg University, Vogt-Kölln-Strasse 30, 22527 Hamburg, Germany
b Department of Applied Nutrition and Food Chemistry, Center for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden
 

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Very interesting read.

Chicken breast pan fried at 175C for 30 minutes has 0.2ng/g of Norharman and 0.1ng/g of Harman. At 220C it is 5.1ng/g and 2.6ng/6.

If you flame broil the chicken for 6 minutes you get 622ng/g and 133ng/g!
So if you got a 1kg chicken you would have 622mg of norharman!?

Any thoughts about doing a chicken extraction? 😁
 

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.i've 'exposed myself ' to up to 300mg Harman (from acacia) on a few occasions..i don't think it's toxic at these levels, but it is a very potent MAOI, or so it seems..more likely to set off dietary amines etc (which would create potential toxicity)..i have also exposed myself to harman via a few Passifloras..'im still here:)..see the passifloras thread..

and thanks In Motion..!
 
Found this:
The b-carbolines norharman and harman showed
only a slight lipophilic character at acidic pH values (pH
2 and 5), but partitioned into the oil phases at pH 8 resulting
in up to 36.8- and 38.4-fold higher levels compared to
the water phases. Different behaviour may be explained
by the different pKa values of the compounds. The pKa values
for norharman and harman are 6.5/14.5 (Draxler and
Lippitsch, 1993) and 7.4/14.6 (Wolfbeis et al., 1982),
Click to expand...
From Degradation of heterocyclic aromatic amines in oil under storage
and frying conditions and reduction of their mutagenic potential

Going to try to extract some from raisins.
 
nen888 said:
.i've 'exposed myself ' to up to 300mg Harman (from acacia) on a few occasions..i don't think it's toxic at these levels, but it is a very potent MAOI, or so it seems..more likely to set off dietary amines etc (which would create potential toxicity)..i have also exposed myself to harman via a few Passifloras..'im still here:)..see the passifloras thread..

and thanks In Motion..!
Click to expand...


I've 'exposed myself' to up to 700mg Harman on a few occasions and all I got out of it was an arrest for public indecency and a couple of restraining orders. I guess a boardroom meeting was the wrong place to try this.


On a serious note, I believe Harman is the active MAOI in tobacco so all smokers will have quite a lot of experience with it, aware or unaware.
 
Norharman seems to be much more bioavailable through sublingual administration. It was 20 fold higher compared to oral administration. It has a relatively short half life in plasma of around 30 minutes. So it is shorter acting than harmine/harmaline.
 
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