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freebase thh + harmine + dmt ratios?

L

lenar

Rising Star
Hello friends, I'm looking to combine ~200mg THH, ~50 harmine and ~50(?) dmt freebase. Are these good ratios? The most information I could find about a blend like this is from user ava69, whom which I now understand to be a blacklisted user who shilled a whole bunch of supps callously, I guess "hpbcd", is not necessary or recommended at all..? I'm unsure about the whole combination. I'm left with these questions that I would really appreciate some help with;
- Is everything to be taken orally? I've read the thh is dosed orally 1hr prior, then the harmine / dmt can be sublingually dosed? Is it really worth it compared to oral?
- Any nausea expected with this combo?
Thank you to anyone who can inform
 
I experimented with sublingual DMT (HPBCD) a couple of years ago. It was never a satisfactory experience because the DMT burns, and you tend to produce a lot of saliva. So, assuming you go with oral harmine and DMT (pharmahuasca), you'll need to dose 150-200 mg harmine, wait 30-60 minutes, then dose 50 mg DMT. You can play around with the harmine dose if you want - say 150 mg, then do an additional 50 mg with the DMT. If you've never done this combo, I'd leave out the THH for now. When you're ready to add the THH, start with 50 mg an hour before the harmine. Increase from there.
 
shroombee said:
I experimented with sublingual DMT (HPBCD) a couple of years ago. It was never a satisfactory experience because the DMT burns, and you tend to produce a lot of saliva. So, assuming you go with oral harmine and DMT (pharmahuasca), you'll need to dose 150-200 mg harmine, wait 30-60 minutes, then dose 50 mg DMT. You can play around with the harmine dose if you want - say 150 mg, then do an additional 50 mg with the DMT. If you've never done this combo, I'd leave out the THH for now. When you're ready to add the THH, start with 50 mg an hour before the harmine. Increase from there.
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Thanks for your input! Do you have any experiences you could share regarding this combo? I loved reading the user experiences from the hpbcd threads, sounded like everyone(not many) who got it to work correctly had a great time. Seems like pure harmine + dmt seems to be more chaotic than with thh added..?

Would 200mg+ thh be enough to orally activate the dmt? Perhaps 200mg thh + 85mg harmine? Sorry for many questions. I've read the reports with THH and loved how its reported to bring a protective, magical feminine type of energy to the experience.
 
IIRC, THH is a weak-MAOI. I don't know whether your suggestion of 200 mg THH + 85mg harmine would work.

Be wary of the glowing ava69 reports. Experience reports are subjective, and ava69 has a reputation for exaggeration. Furthermore, his dosage recommendations are way too high for most people. His disregard for the safety of others is partially why the moderators felt it necessary to eject him from the community.

I've used THH with mushrooms, DMT, and mescaline. If you're taking an average dose of mushrooms or DMT, 200 mg THH is too much. You'll have a rough time with that. With mescaline, 200 mg THH is reasonable and will potentiate the trip.
 
shroombee said:
IIRC, THH is a weak-MAOI. I don't know whether your suggestion of 200 mg THH + 85mg harmine would work.

Be wary of the glowing ava69 reports. Experience reports are subjective, and ava69 has a reputation for exaggeration. Furthermore, his dosage recommendations are way too high for most people. His disregard for the safety of others is partially why the moderators felt it necessary to eject him from the community.

I've used THH with mushrooms, DMT, and mescaline. If you're taking an average dose of mushrooms or DMT, 200 mg THH is too much. You'll have a rough time with that. With mescaline, 200 mg THH is reasonable and will potentiate the trip.
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ill be mindful of that, thank you. potentially saved me from a bad time.
 
hello again, ive researched the combinations more, i would like to attempt 80mg harmine + 40mg THH + 25mg dmt. would anyone be able to help me understand the dosing regimen? i see a bunch of conflicting info. from what i understand,

- empty stomach
- dose thh orally
- 1 hour after, dose harmine orally
- 10-15min after, dose dmt orally alongside a small amount of carbs to stimulate digestion
- success

ive seen people split their harmine dose into sections - for example they'll do something like;

1/3rd of their harmine dose orally -> wait 30min -> then next harmine dose -> 10min -> dmt dose -> dose rest of harmine sublingually. to ensure that its all saturated and such. would this be more effective? should i concern myself at all with dosing thh/harmine sublingually? i dont mind the extra work to ensure a smooth and consistent experience.
 
People have their favored methods. There isn't any universally agreed-upon recipe. As I mentioned previously, THH is a weak MAOI. It doesn't substitute for a proper dose of harmine to orally activate DMT. Your suggestion of 80 mg harmine + 40 mg THH + 25 mg DMT sounds low for harmine. Bump up the harmine to at least 120 mg, and the combination has a better chance of working.

Personally, I can get by with 100 mg harmine and 15-30 mg DMT for a light pharmahuasca trip (no need for a trip sitter, about an hour of entertaining CEV, a consistent sense of self, with some occasional dizziness or anxiety as the trip intensifies). I dose the harmine, wait 15 minutes, then dose the DMT. My dosing is low for most people, though.

Most pharmahuasca recipes are 150-200 mg harmine and ~50 mg DMT. The 150-200 mg harmine is what's typical to fully activate the DMT, and that's the foundation of pharmahuasca.

I don't think sublingual harmine will work for oral DMT. The harmine needs to deactivate the gut's MAO enzymes so the DMT is not broken down.

I also recommend you keep a journal, document your dosages and timing, and take notes of the effects along the way. Trial and error is part of the practice of using these substances and figuring out what works best for you.
 
Pharmacological footnote:
The major action of THH seems to be as a serotonin reuptake inhibitor; its MAOI properties are negligible by comparison.

www.ncbi.nlm.nih.gov

The pharmacological interaction of compounds in ayahuasca: a systematic review

Ayahuasca is a South American psychoactive plant brew used as traditional medicine in spiritual and in cultural rituals. This is a review of the current understanding about the pharmacological mechanisms that may be interacting in ayahuasca. Searches ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
 
shroombee said:
People have their favored methods. There isn't any universally agreed-upon recipe. As I mentioned previously, THH is a weak MAOI. It doesn't substitute for a proper dose of harmine to orally activate DMT. Your suggestion of 80 mg harmine + 40 mg THH + 25 mg DMT sounds low for harmine. Bump up the harmine to at least 120 mg, and the combination has a better chance of working.

Personally, I can get by with 100 mg harmine and 15-30 mg DMT for a light pharmahuasca trip (no need for a trip sitter, about an hour of entertaining CEV, a consistent sense of self, with some occasional dizziness or anxiety as the trip intensifies). I dose the harmine, wait 15 minutes, then dose the DMT. My dosing is low for most people, though.

Most pharmahuasca recipes are 150-200 mg harmine and ~50 mg DMT. The 150-200 mg harmine is what's typical to fully activate the DMT, and that's the foundation of pharmahuasca.

I don't think sublingual harmine will work for oral DMT. The harmine needs to deactivate the gut's MAO enzymes so the DMT is not broken down.

I also recommend you keep a journal, document your dosages and timing, and take notes of the effects along the way. Trial and error is part of the practice of using these substances and figuring out what works best for you.
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thank you very much you've been very informative
 
shroombee said:
I don't think sublingual harmine will work for oral DMT. The harmine needs to deactivate the gut's MAO enzymes so the DMT is not broken down.
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I don't have experience with pharmahuasca, but sublingual harmaloids works very well for psilohuasca. It seems to me that MAO works somewhere else in the body, not in the gut.
 
doubledog said:
I don't have experience with pharmahuasca, but sublingual harmaloids works very well for psilohuasca. It seems to me that MAO works somewhere else in the body, not in the gut.
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It's an enzyme that helps digestion and is found in the gut, it is well used by mitochondria as well as in the pre and post synapses of the neurons where it effectively helps recycle excess neurotransmitters. Hence why it has quite a profound effect on psychedelic compounds and the brain, it can't 'recycle' or 'cleanse' the compounds from the neurons as fast. (as well as ayahusca in the gut-where it inhibits MAO allowing dmt to enter through the digestive system).
 
Thanks, _Trip_, for the explanation, so it looks like that it inhibits the enzymes in the gut even with sublingual administration. Quite interesting.
 
Sublingal will put it straight into the bloodstream and be carried systemically so there would be some gut MAO inhibition, I'd wager taking it orally would have more effect at targeting these sites this would be only really applicable for oral dmt use (as dmt is broken down in the stomach rendering it ineffective as it never makes it to the brain without the MAOI). In terms of pilohusca as you mentioned, it's all brain neuron MAO inhibition as the cause of these effects. Gut MAO inhibition has no effect on the mushrooms as psilocybin gets dephosphorylated in the liver to psilocin iirc).
 
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lenar said:
Hello friends, I'm looking to combine ~200mg THH, ~50 harmine and ~50(?) dmt freebase. Are these good ratios? The most information I could find about a blend like this is from user ava69, whom which I now understand to be a blacklisted user who shilled a whole bunch of supps callously, I guess "hpbcd", is not necessary or recommended at all..? I'm unsure about the whole combination. I'm left with these questions that I would really appreciate some help with;
- Is everything to be taken orally? I've read the thh is dosed orally 1hr prior, then the harmine / dmt can be sublingually dosed? Is it really worth it compared to oral?
- Any nausea expected with this combo?
Thank you to anyone who can inform
Click to expand...
ill be doing more tests myself alongside the advice given here in coming months
 
impermanent-tao said:
ill be doing more tests myself alongside the advice given here in coming months
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me aswell. ill post updates here, dug through archives and am going to try a whole bunch of different modalities. im also curious if anyone can reciprocate- how does this information change based off of vaporhuasca? say i dose 35mg harmine sublingually and ~200mg thh, will that potentiate the trip? interested to know if the overstimulation of thh is from the high harmine due to it being needed for maoi
 
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