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GLP-1 Interactions

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Psychonauti

Rising Star
Does anyone here take GLP-1 meds like Ozempic, Wegovy, Moujaro, Zepbound, Saxenda or Liraglutide?

I've been searching the internet to find people like me who take a GLP-1 med and is interested in taking DMT.

Is anyone else on this and if so, how do you ensure that you're trip/experience isn't affected?
 
I don't know a lot about GLP-1 medications, but some cursory research suggests there isn't any direct interaction as GLP-1 doesn't have any serotonergic activity. I'd be wary of combining these materials with harmalas/oral DMT due to the way they slow metabolism and they do seem so have some cardiovascular effects as does DMT so I'd be wary of this combination for those with existing heart conditions.
 
If you're concerned about the meds specifically, you can try temporarily replacing them with freshly-brewed, unsmoked yerba-maté (Ilex paraguariensis) tea. Research shows that the dicaffeoyl quinic acids and matesaponins in it markedly increase GLP-1, so you'll achieve the same (although weaker) effect compared to the meds you mention, which would allow you to perhaps indulge in DMT without worrying as much about perscription drugs. That's just an idea though, I would recommend discussing this with your MD, as I have no idea what risk does interrupting your cycle with these meds carry.

Good luck!
 
I've been taking semaglutide for 10 or 12 weeks. It has had no noticeable effect on smoking. I do notice if I eat shrooms or a THC edible, though. The effects seem milder and prolonged, which makes sense considering the slower digestion.
 
supervilian said:
I've been taking semaglutide for 10 or 12 weeks. It has had no noticeable effect on smoking. I do notice if I eat shrooms or a THC edible, though. The effects seem milder and prolonged, which makes sense considering the slower digestion.
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That's good to hear!

What things do you do to potentiate the effects of the shrooms, if any?

Also, have you ever done ayahuasca?
 
Psychonauti said:
That's good to hear!

What things do you do to potentiate the effects of the shrooms, if any?

Also, have you ever done ayahuasca?
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I have sadly not tried ayahuasca. I just recently came across this forum researching methods for DMT extraction. But with shrooms, I haven't had a good opportunity to see the effects of a full dose. I just capped up a bunch from my last grow and took a gram which normally would be a chill day deep in thought, but instead, I fell asleep for 4 hours right as the hit. I've been on a different SSRI though which may be a factor, my previous one seemed to amplify, but looking it up it seems they generally seem to blunt the effects.
 
@supervilian I'm sure you already know this, but just a reminder for everyone reading this. Do not mix ayahuasca with an SSRI, that is a recipe for serotonin syndrome.

Harmalas are generally pretty forgiving, and a lot of the MAOI contraindications don't apply to RIMA's, but that combination is truly dangerous.

Stay safe frens. ❤️
 
supervilian said:
I have sadly not tried ayahuasca. I just recently came across this forum researching methods for DMT extraction. But with shrooms, I haven't had a good opportunity to see the effects of a full dose. I just capped up a bunch from my last grow and took a gram which normally would be a chill day deep in thought, but instead, I fell asleep for 4 hours right as the hit. I've been on a different SSRI though which may be a factor, my previous one seemed to amplify, but looking it up it seems they generally seem to blunt the effects.
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Oh, that's interesting!

I've heard that psychedelics and SSRIs have interactions (as in lessening the potentiality) but I didn't know some could amplify. Do you mind telling me which one amplified?
 
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