I'm a very experienced user with Rue, i've taken it very regularly over the years. Here lately, i've been taking it daily for a little over 2 months now, started out with 2 to 2.5 grams, then a few weeks later upped it to like 3 to 3.5 grams, then after a couple weeks i upped it to 4.5 grams, been taking 4.5 grams for the last 3 weeks. I've been building up the Harmala reverse tolerance, i've been using roasted Rue seed powder capsules, there's been absolutely no nausea or vomiting or gut discomfort of any kind since i started this. But i also take some Limonene for heartburn which may also help with nausea/vomiting, i'm pretty sure. I take usually 10 drops of Limonene in a capsule once a day, at night before bed, and it lasts on into the next day, not sure if that's why i haven't had any nausea/vomiting from the Rue, but it's worth investigating imo. It also helps to clean up the Rue in terms of how it feels a good bit. Here lately i've also been adding about 45mgs of Caffeine (using 10ozs of mtn dew) to wash the Rue down with and the Caffeine content helps to counteract the sedation and makes things more functional. I used to include Lemon Balm with the Rue but haven't done that in a bit now. The Rue for me is very functional for the most part, have really no side-effects that i've noticed, and i plan to keep taking it daily for the next few months, maybe longer. I once took Rue extract daily for 8 months straight, and have worked with Rue/Harmalas regularly since 2012. I really recommend adding things with it, using it as a base for a medicinal "stack" of sorts. I've also not needed to avoid anything dietarily, as there are no Tyramine interactions with the Rue/Harmalas, so just keep that in mind. If you get a headache from Rue, it's not Tyramine, chances are it's vasodilation, or it could be inflammation if you have some tooth issues (i have tooth issues, if i don't have an anti-inflammatory i can get quite the headache, though Rue does have some anti-inflammatory properties, but ibuprofen or fish oil seems to work best ime). Do wanna keep in mind drug to drug interactions though, primarily SSRI's, Amphetamines, things metabolized by CYP2D6 or CYP1A2 which Harmalas inhibits. I've also noticed that the more the Harmala dosage increases, the longer the duration of the Harmala effects is stretched out, it goes from 6 hours, to 8 hours, to 10 hours, potentially even up to about 12 hours or longer, depending on the dosage.