Bookmark for myself (and for feedback):

One of the problems extracting the harmala acetates from rue is that the vinegar/water solvent is very non-selective, and drags along many undesirables. Harmala acetate is not very soluble in many common solvents (methanol, ethanol, etc). An the alkaloid form is generally not soluble.

So might it make sense to first extract the undesirables from the seeds with a solvent that won't select harmala salts? The amount harmalas lost in the process might be made up for by not having to filter and wash as much. Microwave use may make this initial extraction quick and efficient.

The question is, what is the most non-selective solvent in which harmala salts are insoluble? Ethenol?Or maybe use Basified water for the alkaloid (perhaps at ph10)?