personally, no i havent
over the last few years out of everyone ive introduced to cactus only 2 had "negative" reactions
the first was in my first year of knowing achuma, i had decided to get the local drug scene crowd to try cactus (hoping it would begin their path to a satisfied life of purpose) i brought this guy fresh cacti and instructed him on the preparation and the process for ingestion. being that he was the ring leader of this band of totally misdirected young adults i gave him the most magnificent specimen of the bunch. i advised that he split it as it was a very thick cutting and a base cutting to boot. he responded memorably with "NA Ill do it all, i do like triple c's n shit" dumbstruck and having already given him the cactus i tried reasoning that he may get another use out of it whereas everyone else had a one time deal, still he refused.
it was several months before i saw him again, infact i didnt realize it was going to be him until i met him under a different name. when i met him originally he was going by the name "phat shawn", this time on a journey to acquire the elusive LSD i was greeted by "Rex" who did a double take when he saw me. whats more is i brought cactus with me again to barter for LSD and he actually stumbled backwards when i brought it out, saying "Get that shit away from me"
Caught between laughing and sincerity i asked about his experience. he told me that he did it the last day of high school, after school and went home and ate it. he proceeded to have a house party. he went to his bedroom and put a towel over his head and stood in the dark closet and began to dance, then feeling more comfortable he came out and went outside to burn his books and papers, dowsing the old texts with gasoline he ignited it and burned off his eyebrows in the following combustion, in the ensuing calamity he tore off his shirt and ran barefoot down the road for several miles, then he felt great and made his way home to appreciate the last of his party and eyebrowlessness.
after hearing this strange tale i asked him if it was really so bad, and he said no, it was just "too intense"...
the second person to have a "bad" experience was a good friend of my girlfriend. having just met her and being as enthusiastic and ubridled about my passion for achuma i offered her some. i began to explain what it was i was offering and general information regarding achuma and the experience, she cut me off and told me she had grown san pedro before. a bit embarrased i preached to someone who grew san pedro i ceased the explanation and having already fasted that day i gave us all a foot out of the tea i had prepared
as the experience wore on my girlfriend and i casually smoked some cannabis and listened to music after showering. we offered this other girl a shower, to herself obviously, and she declined (first mistake imho, you dont refuse mews achuma advise having 0 experience yourself

)
she began complaining of not liking aspects of our apartment, she didnt like the music, she didnt like the decor, she felt sick, she blah blah blah, she focussed on negatives. more time went by and she remained totally silent lying on the floor. at hour 4 she reached up and and exclaimed "o my god" and that was it. dumbstruck my girlfriend and i looked at each other and kept enjoying the music and smoking some more cannabis. this girl an hour later decided she needed to go home, so she left after i made sure she had decent enough motor skills to make the quarter mile walk.
later she explained that she was totally unprepared for how strong it was going to be having never done cactus (i assumed she knew as she grew it but she had literally only grown one in her window cill for a few months) also, while she was at our house there were voices telling her how aweful she was and even when she was explaining how she didnt like the things in the house she was rising and falling in extreme time dilation, she told me i would teleport around the room as our conversation continued....
as it turns out she is a hooker, funny right?
in conclusion people who approach cactus in a narcotic light or lead a totally unwholesome lifestyle are in for a bit of a stark revelatory experience