Heating IPA/Acetone to make FASI/FASA

[justine]

Hi,

I'm performing my first extraction with d-limo and FASI, I have realized that fumaric acid is much more soluble in heated IPA, however is there be any reason why
it would be better to just let the IPA+fumaric acid at room temp for a few hours or a day so it completely dissolves ?

Also, do you know the solubility of fumaric acid in IPA ?

Thanks!

 

[InMotion]

I'm not sure on the solubility. Although when using IPA/Acetone if solubility is the main issue, why not simply increase the volume of solvent to solvate the necessary amount of fumaric acid?

For simplicities sake, I'd use a larger volume.

 

[endlessness]

If you warm it up, if you add the warm FASI/FASA to your dmt-containing solvent, then when it cools down, maybe some excess fumaric acid will crash out together with your fumarates, so they will be less pure (speculation from my part).

Either do it in room temperature (just shake the hell out of your container with Acetone/IPA and excess fumaric acid, then decant/filter and use it), or warm it up to dissolve more but let it cool before using.

As for solubility of fumaric acid, im attaching the following publication:

Dang et al. J. Chem. Eng. Data, 2009, 54 (11), pp 3112–3113
Solubility of Fumaric Acid in Propan-2-ol, Ethanol, Acetone, Propan-1-ol, and Water