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Welcome to the Nexus!PAWS is a serious challenge to overcome and is more protracted with the longer acting mu agonists (especially methadone); buprenorphine is only a partial agonist but it binds the receptors with a passion.I dont know if switching from a low dose of suboxone to tramadol would be the way to go.I agree, switching to a shorter-acting mu agonist for a few weeks before taking the iboga would be wise, but tramadol is quite a weak mu agonist (one of its metabolites is more potent in this respect) plus has effects on serotonin and noradrenaline receptors which have their own distinct (and by all accounts, unpleasant) withdrawal effects.I think making this switch would cause more immediate 'lack of satisfaction' then say switching to compounds such as morphine, oxycodone or heroin.I personally would choose one of these three, depending on availability.I also think that its not established clearly how iboga alkaloids would affect someone who had their mu, serotonin and noradrenaline receptors 'fatigued' by tramadol.I would strongly advise that this be borne in mind.Best of luck.
Welcome to the Nexus!
PAWS is a serious challenge to overcome and is more protracted with the longer acting mu agonists (especially methadone); buprenorphine is only a partial agonist but it binds the receptors with a passion.
I dont know if switching from a low dose of suboxone to tramadol would be the way to go.I agree, switching to a shorter-acting mu agonist for a few weeks before taking the iboga would be wise, but tramadol is quite a weak mu agonist (one of its metabolites is more potent in this respect) plus has effects on serotonin and noradrenaline receptors which have their own distinct (and by all accounts, unpleasant) withdrawal effects.I think making this switch would cause more immediate 'lack of satisfaction' then say switching to compounds such as morphine, oxycodone or heroin.I personally would choose one of these three, depending on availability.
I also think that its not established clearly how iboga alkaloids would affect someone who had their mu, serotonin and noradrenaline receptors 'fatigued' by tramadol.I would strongly advise that this be borne in mind.
Best of luck.