Well, my buddy’s experiences with psychedelics and such are as follows:
Decades ago, during the height of the hippy era, my buddy did acid, maybe six or eight times. Several of those times he got some nice OEVs.
One of those times he was in CA with a friend. They wanted some acid, so they just went down to a local strip mall and asked hippies if they had any. One kid said his dad had some and that he would be along shortly, so they waited for him. When his dad showed up, he sold them two hits of acid.
Then they went to a canyon where they knew some hippies were camping to get some pot. They got it, and wound up also getting two more hits of acid called "blue pentagons". They were tiny, maybe about a 1/10" across and no thicker than a sheet of paper, brilliant medium-shade blue, and perfectly pentagonal.
So when my buddy and his friend went back to their friends' house where they were staying, they gave the other acid to their friends and did the blue pentagons themselves. By then it was almost midnight.
It turned out the blue pentagons were several times stronger than anything else my buddy had ever done before or since. He was scared at first, but then he got so high he forgot about everything but the intense trip he was on, so he wound up having a great time, even though he never wanted to do anything that strong ever again.
For hours on end, my buddy and his friend were just looking around the room without saying anything, staring at the absolutely incredible OEVs, and whenever their eyes met, they'd just laugh their asses off because they could each instantly see how high the other guy was. Then after a minute or so, they’d forget what they were laughing about and just start looking around the room again. This cycle must have repeated itself scores of times (if not hundreds) for the entire time they were peaking, which was maybe four hours. My buddy was fine in the morning, but his friend had a splitting headache.
My buddy also did peyote a few times. He liked it, but aside from the horrible taste and vomiting, he didn't get much in the way of OEVs.
About twelve to ten years ago, a friend of my buddy got into growing some cubensis (“B+” strain). So a small group of their friends got into doing those for a couple years, maybe a total of about a dozen times. A few times they did them with ground Syrian Rue seeds to potentiate them. (And yes, they were very careful with their diets for about two whole days each time, to avoid an MAOI reaction.)
Around the same time, another one of the guys in this group of friends got into growing a Dutch strain of pot called Cindarella 99, which he'd share with my buddy. He would only grow two to four plants at a time, but he really did it up right with the lights and hydro system and plant hormones and everything. He even put bubblers into each hydro pot to highly aerate the roots when the pots were flooded (even though it was a flood and drain system that he had set up to constantly flood and drain around the clock), so even when the plants were flowering, the roots continued to grow to an enormous size, and they were snow white. He would prune the plants into about 8 tops each, painstakingly trellising each individual top so they would all get as much light as possible. When he forced them to flower, the buds grew to maybe 8" to 14" long and, before drying, about 4” to 6" in diameter, and about half that after drying. The smell was delicious, kind of piney, and super strong - if you opened a film canister containing a gram of it, it would stink up the whole room in a minute. And WOW, was it potent, with a terrific quality high.
He even made hash out of a little of it. He got two screens, one with a mesh size of 100 (he doesn't remember what the unit of measurement was), and one with a mesh size of 70. Then he'd dry the buds bone-dry, pulverize them to fine powder (gently so as not to rupture the trichomes), sift the powder through the top screen (the 100 mesh one), and collect only the largest, most mature trichomes on top of the bottom, 70 mesh screen (which everything else fell through). This hash was so strong that he once turned a super pot head onto one hit of it, and that guy got such a rush he honest-to-God had to go down on one knee so he wouldn’t fall on his face.
But since then my buddy's been more or less out of the loop. All he's been doing is smoking a little commercial-grade pot when his friends turn him onto it. And he drinks some moderately good wine and some top-quality beer.
So far my buddy’s done only one extraction, which you can read about in my thread “why I want full membership”, which is posted in this forum.