You should make sure your heart is ok, if your fit and healthy then you probably have nothing to worry about but a lot of people get an ECG before to make sure there are no problems. Ive only taken it once and I couldnt walk for for 20 odd hours, if you do try to move you completely lose your balance as you get bad ataxia. I was still really dizzy when trying to crawl around, just in comparison to say an acid freak out your not going to be able to run around and cause yourself harm, just getting to the toilet if you have to can be a challenge. It was very physical and the hardest psychedelic ive done, the purge was painful and hard, could be a shock if you havent purged on aya, wasnt that hard psychologically for me I actually felt I could have handled more but at the tail end of the experience I was saying this is hell never again, but then id love to again at a higher dosage but its expensive stuff!!