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Ibogaine in Silene undulata

_Trip_

_Trip_

Titanium Teammate
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Cant access the paper but would like just to known if their results are based solely on database matching or software-based spectral prediction or confirmation via reference compound. The fact they got similar 5-HT2A affinity between ibogaine and LSD it's alreadt very suspicious for me.
The paper got 0 citations despite the unprecedented finding
 
Sounds suspiciously like another case of column cross-contamination, if you ask me, if it's not just down to sloppy identification methods. The caryophyllaceae ain't exactly big on indole alkaloid biosynthesis. There would have to be a whole set of enzymes for ibogaine production, along with the corresponding intermediates cropping up in the analysis. A DNA sequencing study is a must.

pubmed.ncbi.nlm.nih.gov

Potential Serotonin 5-HT2A Receptor Agonist of Psychoactive Components of Silene undulata Aiton: LC-MS/MS, ADMET, and Molecular Docking Studies - PubMed

These findings provide insights into the potential therapeutic benefits of <i>S. undulata</i>, supporting its traditional use as a psychoactive plant. This study investigated the chemical constituents and potential serotonergic agonist activity of <i>S. undulata</i> for the first time. While...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

There's this reference in the (decidedly dubious) 'herbspedia' website:
Papadodima, Stavroula A., et al. "Ibogaine related sudden death: a case report." Journal of forensic and legal medicine 20 (7) 2013: 809-811
pubmed.ncbi.nlm.nih.gov

Ibogaine related sudden death: a case report - PubMed

Ibogaine is a naturally occurring alkaloid derived from the roots of the rain forest shrub Tabernanthe iboga. Deaths have occurred temporarily related to the use of ibogaine. However, although not licensed as therapeutic drug, and despite evidence that ibogaine may disturb the rhythm of the...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Doesn't seem to relate to Silene sp. in any way.
 
That's my tought, it seems similar to the Acacia berlandieri case to me.
I'll try to get the paper.

In Italy we got Mr. Giorgio Samorini who keep posting about dubious findings as they were facts: ibogaine in Silene capensis, amphetamine in D. stramonium, oxycodone in Epipactis, Baccharis flabellata stronger than Salvia divinorum, scopolamine and deliriants in Lactuca, etc. I guess he doesn't even read the full text of a scientific paper, it's sad when a old childhood hero of turns into a quack.
 
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