Researches seem to have found how to modify "benzos" to boost therapeutic properties and reduce side effects in clinical pre-trials.
They modified imidazobenzodiaze-pines (e.g. flumazenil) to target only certain GABA receptors. Looks like this was done in modeled simulations first and then they moved to synthesis and in vivo testing.
Paper title (attached): Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles
Press release
Interesting and apperently powerful technique. Makes one wonder if any improvements could be done to psychedlic's therapeutic effects (psychoplastogenic and/or cathartic) with a similar technique.
They modified imidazobenzodiaze-pines (e.g. flumazenil) to target only certain GABA receptors. Looks like this was done in modeled simulations first and then they moved to synthesis and in vivo testing.
Paper title (attached): Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles
Press release
Interesting and apperently powerful technique. Makes one wonder if any improvements could be done to psychedlic's therapeutic effects (psychoplastogenic and/or cathartic) with a similar technique.