entheogenic-gnosis
Rising Star
P. nitida seeds contain a mixture of alkaloids producing antipyretic and antiinflammatory effects along with analgesia.[3][4] Several of these were shown to bind to opioid receptors in vitro, and two compounds, akuammidine and ψ-akuammigine, were found to be potent μ-opioid agonists, although not particularly selective. Surprisingly the main alkaloid from the seeds, akuammine, was found to be an opioid antagonist when tested in vitro and canceled out the effects of the active agonist components.[5] This finding contradicts the belief by some pharmacological scientists that there are no naturally occurring opioid antagonists.
en.m.wikipedia.org
Picralima nitida seeds are commercially available and are not scheduled, controlled or regulated. I have had much interest in natural µ-opioid delta and kappa opioid receptor agonists for the purpose of aiding opioid withdrawal, with compounds which include a prolonged withdrawal such as methadone in mind.
Mitragynine is a natural indole µ-opioid receptor agonist which I have looked into for this purpose as well, this compound is available as "kratom" extract sold in smoke-shops, and I believe that perhaps a mix of Mitragynine and related alkaloids derived from Mitragyna speciosa along with natural opioid receptor agonist from other plant sources such as P. nitida seeds, along with dextromethorphan and small amounts of harmala alkaloids may be a good place to begin.
Anyway, as Picralima nitida seeds contain an opioid receptor antagonist as their primary alkaloid (though this compound is likely eventually metabolized into an agonist in vivo)
I would be interested in learning about the process for extracting akuammidine and ψ-akuammigine from P. nitida seeds, while leaving behind any akuammine. Though I'm sure extracts may be commercially available, it could end up being more efficient and cost effective to preform an extract from the seeds themselves, provided the procedure is fairly simple ans requires common solvents and reagents.
I also believe that these natural indole opioids in combination with Racemorphan May be benneficial for aide in withdrawal. dextromethorphan is an over the counter opioid/NMDA receptor agonist and has been effective in opioid withdrawal, however the levatory enantiomer is a full µ-opioid receptor agonist, which leads me to believe that racemorphan would be optimal for this purpose, specially if combined with Mitragynine and akuammidine and ψ-akuammigine, perhaps even with small amounts of harmala alkaloids (which share structural similarity to ibogaine) added into the mix.
I'm still searching for novel compounds or novel combinations of compounds for aide in prolonged opioid withdrawal, such as from methadone. In this country ibogaine detox is not an option and most doctors will send an opioid addict to a methadone program before inpatient rehab. Methadone may reduce harm as in the addicts are not using needles or breaking the law, but it does nothing to treat addiction, methadone patients are still very addicted, they still must be concerned about enduring a hellish withdrawl if they miss even a single dose, they are still subject to the compounds narcotic effects and are still subject to serious physical and injury and other health issues as a result of their methadone addiction. Ibogaine May eventually make it to the states, but until that time I feel I may be able to devise some concoction of unscheduled compounds which will provide relief during tough withdrawal and prevent relapse.
The natural indole opioid compounds caught my attention simply because of my in depth study of tryptamines and other psychedelic indole compounds, however I'm open to researching any compound out there that may serve this purpose regardless of structure or natural availability.
-eg

Akuammine - Wikipedia
Picralima nitida seeds are commercially available and are not scheduled, controlled or regulated. I have had much interest in natural µ-opioid delta and kappa opioid receptor agonists for the purpose of aiding opioid withdrawal, with compounds which include a prolonged withdrawal such as methadone in mind.
Mitragynine is a natural indole µ-opioid receptor agonist which I have looked into for this purpose as well, this compound is available as "kratom" extract sold in smoke-shops, and I believe that perhaps a mix of Mitragynine and related alkaloids derived from Mitragyna speciosa along with natural opioid receptor agonist from other plant sources such as P. nitida seeds, along with dextromethorphan and small amounts of harmala alkaloids may be a good place to begin.
Anyway, as Picralima nitida seeds contain an opioid receptor antagonist as their primary alkaloid (though this compound is likely eventually metabolized into an agonist in vivo)
I would be interested in learning about the process for extracting akuammidine and ψ-akuammigine from P. nitida seeds, while leaving behind any akuammine. Though I'm sure extracts may be commercially available, it could end up being more efficient and cost effective to preform an extract from the seeds themselves, provided the procedure is fairly simple ans requires common solvents and reagents.
I also believe that these natural indole opioids in combination with Racemorphan May be benneficial for aide in withdrawal. dextromethorphan is an over the counter opioid/NMDA receptor agonist and has been effective in opioid withdrawal, however the levatory enantiomer is a full µ-opioid receptor agonist, which leads me to believe that racemorphan would be optimal for this purpose, specially if combined with Mitragynine and akuammidine and ψ-akuammigine, perhaps even with small amounts of harmala alkaloids (which share structural similarity to ibogaine) added into the mix.
I'm still searching for novel compounds or novel combinations of compounds for aide in prolonged opioid withdrawal, such as from methadone. In this country ibogaine detox is not an option and most doctors will send an opioid addict to a methadone program before inpatient rehab. Methadone may reduce harm as in the addicts are not using needles or breaking the law, but it does nothing to treat addiction, methadone patients are still very addicted, they still must be concerned about enduring a hellish withdrawl if they miss even a single dose, they are still subject to the compounds narcotic effects and are still subject to serious physical and injury and other health issues as a result of their methadone addiction. Ibogaine May eventually make it to the states, but until that time I feel I may be able to devise some concoction of unscheduled compounds which will provide relief during tough withdrawal and prevent relapse.
The natural indole opioid compounds caught my attention simply because of my in depth study of tryptamines and other psychedelic indole compounds, however I'm open to researching any compound out there that may serve this purpose regardless of structure or natural availability.
-eg