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Well according to table 3 in that paper I posted it appears as if safrole is more of a depressant and myristicin is more of the hallucinogen as well as elemicin. So the theory that you are developing may be true. However separating these components from one another would be very tricky. The wide range of effects reported by users of these substances could have to do with so many things such as sample preparation and starting concentrations as well as ratios of the compounds of interest.


Shulgin AT, Sargent T, Naranjo C. The chemistry and

psychopharmacology of nutmeg and of several related

phenylisopropylamines. In: Ethnopharmacologic Search

for Psychoactive Drugs. Efron DH, Holmstedt B, Kline

NS, eds., Washington: US Government Printing Office,

1967:202–214.


Duke JA. Handbook of phytochemical constituents of

GRAS herbs and other economic plants. Boca Raton, FL:

CRC Press, 1992.


Truitt EB, Callaway E, Braude MC, Krantz JC. The pharmacology

of myristicin: A contribution to the psychopharmacology

of nutmeg. J Neuropsychiat 1961;2:

205,210.


These are the citations of interest. But again the evidence is scant but still at least theres been some studies.


Also again this is all about nutmeg the alkaloids in sassafras could still be interesting or perhaps psychoactive compounds. No one knows.


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