Yeah, that paper says safrole is an anticonvulsant, Ca antagonist (calcium channel blocker), CNS depressant and anesthetic.

So it seems to support my idea that washing sassafras with MEK is removing a sedative and that sedative is probably safrole, as I figured.

It doesn’t list safrole as a hallucinogen.

This bit of information is helping to piece this together.

Here’s the info it supplies on myristicin and elemicin:

Myristicin: Ca antagonist, hypotensive, sedative, antidepressant, hallucinogen, anesthetic, serotonergic

Elemicin: antidepressant, hallucinogen, antihistaminic, hypotensive, antiserotonergic

What’s interesting is that it lists elemicin as antiserotonergic and myristicin as serotonergic. It also lists elemicin as antidepressant and myristicin as sedative.

I don’t know how accurate that paper is, but assuming it’s accurate, elemicin looks like a far better hallucinogen than myristicin does. That would help explain the purely positive trip reports I’ve seen on elemicin from elemi oil. It’s both an antidepressant and a hallucinogen, while myristicin is a sedative and hallucinogen.

Hallucinogens that are antidepressants include things like MDMA, mescaline, etc. These are some of the more pleasant hallucinogens. Elemicin is nearly identical to mescaline in it’s chemical structure. So it would make sense that it is both hallucinogenic and an antidepressant. Mescaline in low doses is an extremely effective antidepressant.

Hallucinogens that are sedatives include things like scopolamine, dimenhydrinate (dramamine), and are usually unpleasant experiences at hallucinogenic doses. I’ve read elsewhere that myristicin is also anti-cholinergic like scopolamine and dimenhydrinate. That doesn’t sound so good, and could easily explain all the unpleasant trip reports there are for nutmeg. Scopolamine and dimenhydrinate are anti-cholinergics, sedatives, and hallucinogens at high doses. Most scopolamine and dimenhydrinate trip reports are unpleasant.

If elemicin is the desired compound in nutmeg, and it looks like it is according to that paper, it may be a good idea to use elemi oil instead of nutmeg oil. Elemicin and myristicin would be hard to separate. Elemi oil lacks myristicin, but is high in elemicin, so it sounds like the way to go.

Take a look at the picture I added. It shows elemicin next to mescaline (it may take a while before the pictures are added, just refresh until you see them).