After reading about this more, turns out that an ion exchange method was published for psilocin/psilocybin.

They used what appears to be a sulfonic based cation resin, similar to what we are working with now but with HPLS. The mushrooms where extracted with acidified methanol and that was loaded into resin with a column geometry. The column was eluted under acidic (pH 3) buffer conditions with increasing ionic strength (250mM) using water and up to 20% ethanol in one of the papers.

So the precedent exists with HPLS (attaching two published works that talk about it and adding the picture below). Something similar may be possible to do here at the nexus using a simple gravity column I hope. We could use ammonium acetate as the ionic elution buffer under slightly acidic conditions and evaporate it off. HPBBCD to protect the vulnerable psilocin while increasing its solubility into the elute may be useful. Finally, arginine could help elute the actives if needed, but may become part of the final product.

I'm also attaching a very nice mushroom review paper that I enjoyed and wished I had found sooner.

Note that I'm backing off work on batch elution since it is proving difficult. Column elution makes sense since the drugs can be pushed out even if some level of affinity exists between the ion resin and the drug.