Ketamine's Cousin

[Philosopher]

Ketamine Cousin Rapidly Lifts Depression Without Side Effects

NMDA or glutamate receptor modulators as antidepressants have come of age. Human clinical studies demonstrated that ketamine can ward off depressive symptoms within 2 hours of administration and last for several days. Yet serious side effects are attached to this drug, including excessive...

www.nimh.nih.gov

An amazing discovery, GLYX-13, like Ketamine, can stop major depression symptoms in a matter of minutes or hours, unlike anything on the market which takes weeks to accumulate in the blood before affecting the brain. This will be used to save 100,000s of suicides in the future, mark my words.

This is awesome. It shows that usable, prescibable medicines can be derived from the psychedelic family. I know Ketamine is not a tryptamine and therefor the pharmocology is very different. However, I think its extremely interesting that they found out how to keep the antidepressant affects, and negate the psychedelic affects. Although it is still "mind manifesting" since it is an antidepressant, users can function and even enjoy increased memory and learning. This is in phase 2 but has been fasttracked by the FDA because of its necessity. This is one of the 1st examples of a psychedelic derived medicine that will most likely be available to those suffering sometime in the near future. I think this molecule "GLYX-13" was able to be discovered because Ketamine is not a schedule 1 drug like most psychedelics. And if we use this as an example as to why they "drugs" need to be removed from schedule 1 because of things we havent even been able to discover yet, I think people will begin to realize just how big of a mistake the government has made.

 

[obliguhl]

That is very, very interesting, as ketamine has great anti-depressant effects on me. I have looked it up and found, there is even a more promising molecule in development by the same company called Apimostinel - Wikipedia .

http://www.fiercebiotech.com/story/naurex-bags-80m-round-phiii-study-nmda-drug-depression/2014-12-03

 

[Ufostrahlen]

Glycine antagonists
These drugs act at the glycine binding site:

GLYX-13 (weak partial agonist; IA = ~20%)
NRX-1074 (weak partial agonist)
L-phenylalanine,[54] a naturally occurring amino acid (equilibrium dissociation constant (KB) from Schild regression is 573 µM[55]).

NMDA receptor antagonist - Wikipedia

en.wikipedia.org

Therapy of depression by phenylalanine. Preliminary note.

To 23 subjects with endogenous depression after a previous unsuccessful treatment with common antidepressive drugs (imipramine-like or MAO inhibitors) dl- or d-phenylalanine was given in dialy oral doses of 50 or 100 mg during 15 days. A complete euthymia was obtained in 17 subjects between one and 13 days of treatment. No important adverse reaction was observed.

Therapy of depression by phenylalanine. Preliminary note - PubMed

To 23 subjects with endogenous depression after a previous unsuccessful treatment with common antidepressive drugs (imipramine-like or MAO inhibitors) dl- or d-phenylalanine was given in dialy oral doses of 50 or 100 mg during 15 days. A complete euthymia was obtained in 17 subjects between one...

www.ncbi.nlm.nih.gov

[DL-phenylalanine as an antidepressant. Open study (author's transl)].

In an open study dl-phenylalanine in doses from 75--200 mg/day was administered to 20 depressed patients for 20 days. At the end of the trial 12 patients (8 with complete, 4 with good response) could be discharged without any further treatment. 4 patients with partially untypical depressions experienced mild to moderate responses, whereas 4 patients did not respond at all to the phenylalanine administration. Depressive "core symptoms" as depressed mood, retardation and/or agitation were preferentially, anxiety and sleep disturbances moderately and hypochondriasis and compulsiveness were not influenced. It is concluded that dl-phenylalanine might have substantial antidepressant properties and that further controlled investigations are justified.

[DL-phenylalanine as an antidepressant. Open study (author's transl)] - PubMed

In an open study dl-phenylalanine in doses from 75--200 mg/day was administered to 20 depressed patients for 20 days. At the end of the trial 12 patients (8 with complete, 4 with good response) could be discharged without any further treatment. 4 patients with partially untypical depressions...

www.ncbi.nlm.nih.gov

The EFSA however isn't that impressed with L-phenylalanine: L-phenylalanine related health claims

 

[Spiralout]

For me dxm, a dissociative, has had definite depression and anxiety relieving properties, more than any other compound has. I have some experience with ketamine and mxe and they too had this effect. However in the long run dxm has left me feeling empty and hopeless however I have started getting over it. These compounds should be used with caution and should not be used on a regular basis imo. If in a really bad bout of depression they can bring some needed relief but that relief can of itself be the start of a habit that has detrimental effects. I can ONLY say this from my experience with dxm however.

 

[blue_velvet]

For me dxm, a dissociative, has had definite depression and anxiety relieving properties, more than any other compound has.

Same here, though it would only last about a day. It gave me a feeling of how I'm supposed to feel. I was a little more confident and aloof and less hung up on the weight of my emotional baggage; took things less personally. This was always on the comedown and I've always associated the feeling with the nature of the experience, i.e. a result of hours spent in detached, cerebral introspection. However, if it's physiological and GLYX-13 can do something similar without being psychoactive, that would be pretty amazing.