LSD as treatment for IBS

[Gone-and-Back]

A friend of mine who suffers from IBS had recently gotten his hands on some LSD. He was not able to handle many types of foods, and would have the hardest time keeping food down. Appetite was very low because of this, and he was underweight as a result. However, after taking the dose that he had acquired, he started to realize that most of his symptoms had started to disappear....There was no longer a lack of appetite, and he has actually gained ten pounds (something previously almost impossible to do). Foods that use to cause flareups for him no longer cause these issues, although some still do to a lesser extent. All this happened after taking that dose, and that was the only thing that had changed in his day to day activities. I think there should be some research done into this as a possible treatment for IBS...He has only done that one dose and to this day has not been effected by his IBS as badly as he use to be, and this is now a few months down the road. Who knows how long this could last? However long it does, its definitely a big relief for him and lifts a great burden.

 

[universecannon]

interesting :]

iirc, dr. andrew weil claims lsd actually cured his cat allergies, and also a life long skin condition that would flare up while spending too much time in the sun

 

[The Day Tripper]

DOI, or 2,5-dimethoxy-amphetamine is a very powerful anti-inflammatory agent. like at 100mcg doses. I believe Someone working with David Nichols was the first to document this iirc.

IIRC, it has something to do with 5ht2a serotonin agonism. LSD has this property as well. I can't imagine how it would provide long term relief from IBS (an inflammatory condition) after one dose, but it does make some sense that its possible at least for temporary relief/treatment.

Pretty interesting stuff if you ask me. Especially considering, at least with DOI, your taking very low, sub-threshold doses, of a long lasting agonist, with not much risk of long term toxicity/side affects relative to currently prescribed/used anti-inflammatory drugs.

I think theres alot to be explored/discovered in regards to treating inflammation, the sad thing is, the only ones that will be used in mass in our society are the profitable ones, not the safest, or most effective, or the ones that actually can treat inflammatory conditions in the long term without losing efficacy or presenting side affects that make them not an ideal choice for people who suffer from chronic inflammatory diseases.

PDE4 inhibitors are something worth looking at as well if your friend is interested in learnig more about promising anti-inflammatory drugs.

 

[Gone-and-Back]

Thats very interesting Tripper, and thanks for the info. He prefers to not take anything at all for it really, he just stays away from what bothers it. Sometimes he doesn't care and does it anyways, and this was the case the day after taking that dose. Magically, the food did not bother him.

 

[jamie]

DOI, or 2,5-dimethoxy-amphetamine is a very powerful anti-inflammatory agent. like at 100mcg doses. I believe Someone working with David Nichols was the first to document this iirc.

IIRC, it has something to do with 5ht2a serotonin agonism. LSD has this property as well. I can't imagine how it would provide long term relief from IBS (an inflammatory condition) after one dose, but it does make some sense that its possible at least for temporary relief/treatment.

Pretty interesting stuff if you ask me. Especially considering, at least with DOI, your taking very low, sub-threshold doses, of a long lasting agonist, with not much risk of long term toxicity/side affects relative to currently prescribed/used anti-inflammatory drugs.

I think theres alot to be explored/discovered in regards to treating inflammation, the sad thing is, the only ones that will be used in mass in our society are the profitable ones, not the safest, or most effective, or the ones that actually can treat inflammatory conditions in the long term without losing efficacy or presenting side affects that make them not an ideal choice for people who suffer from chronic inflammatory diseases.

PDE4 inhibitors are something worth looking at as well if your friend is interested in learing more about promising anti-inflammatory drugs.

Anti inflamatories are not going to cure inflamatory bowel disease though..I know cus I have it. Irritable bowel syndrom and inflammatory bowel disease are not identical. It would have to be some other aspcet of the LSD's action that would cure it. Anti inflammatories might cure the symptoms for a time though. It could be that the LSD changed something about the psychology of the person making them less anxious, which is somewhat connected to bowel disorders.

 

[Gone-and-Back]

That sounds very plausible Jamie, whatever the reason it should be looked into.

 

[hixidom]

LSD often gives me diarrhea at some point during the trip. Just throwing that out there.

 

[Gone-and-Back]

Really hix? I have never heard of anyone experiencing that, I am very glad that does not happen to me.

 

[corpus callosum]

Irritable bowel syndrom and inflammatory bowel disease are not identical.

IBS, in medical parlance, refers to irritable bowel syndrome, and as Jamies stated, is significantly different to inflammatory bowel disease (classically Crohns disease and ulcerative colitis). IBS is not associated with detectable inflammation and is best regarded as a functional disorder and serotonin figures highly in brain-bowel communication hence its not a surprise that compounds affecting serotonin can have gastrointestinal effects. Theres a compound called Tegasarod which is a 5HT4 agonist which is used for IBS with predominant constipation but there was some concern regarding this and vascular complications which led to its withdrawal from the US market.5HT3 antagonists such as Ondansetron have been used in diarrhorea-predominant IBS but is more commonly used as an anti-emetic.SSRIs also very commonly cause gastrointestinal effects, particularly on initiation.