Jimson weed is dangerous. But in very low doses it's not and has many medical uses. The problem is lots of people try taking tons of seeds to get "hallucinations". The hallucinations one gets from Jimson weed look completely real to you, you cannot tell the difference between what’s real and what’s not, and during that state of delirium you are extremely stupefied and you could very easily slip into a coma or die. The doses needed for that type of experience from Jimson weed are on the verge of being fatal. Jimson weed has a bad wrap from people taking overdoses of it to get “hallucinations”. That’s very dangerous. Many people have died from that.

I don't want anyone to get the wrong impression about Jimson weed. It can be fatal if you don't know what you're doing. 1-3 seeds are considered safe for adults. Once you go beyond 10 seeds (the maximum safe dose for herbal medical purposes), you’re getting into extremely risky territory. People taking 50-100 seeds to get delirious from it are risking their own sanity, the safety of others around them, and risking their own lives.

I've seen reports of as little as 15 seeds of an unknown Datura plant causing delirium. These were probably not Jimson weed seeds, but much larger seeds from a different Datura. Some Datura have larger seeds than Jimson weed, and they can contain much more alkaloids by seed count because they’re larger. Rather than judging dosage by seed count which requires 100% accurate species identification, it’s better to weigh them and use no more than 24 mg of Jimson weed seeds (about 3 seeds if correctly identified).