Mescaline tolerance?

[endlessness]

Anybody has experience with consuming cactus on consecutive days or two days after? Is there build up of tolerance?

I think I remember house saying there was none.. Throughout the internet there is conflicting info.. So who got personal experience to share?

 

[nicechrisman]

I'd imagine there's some tolerance, but I think it is WAY less than things like LSD and mushrooms. I've heard of people doing multiple day sessions. In fact, if I'm not mistaken, it is sometimes taken that way traditionally in Peru. Also in the peyote meetings, I hear they just keep eating it during the whole meeting, which lasts all night.

 

[SHroomtroll]

My experience tells me that mesc builds alot slower than lsd or mushrooms, also it seems to not create as much tolerance for other drugs that are similar.

I think i could def trip 2days in a row and only drink a little more the second day to acheive full effects.

But i am also very sensitive to most drugs and my tolerance seems to build slowly aswell since ive tripped like 4times in one week on acid and didnt need inhuman amounts the last night.



Im not sure how or why but bost mesc and oral dmt seems to work in alot more psychological ways than chemc like lsd or 2c-x which are alot more dose dependant.

 

[DeDao]

I have had cactus two days in a row before.

Day 1 I had 9 inches. Day 2 I had 15 inches.

Day 2 was only mildly more intense.

Mathematically speaking this shows that there is a tolerance. (assuming the ratios are equal)

That's is my experience.

I would say if doing it two days in a row up the dose by 25-33% in order to achieve similar effects as the day before.

 

[jamie]

I'd imagine there's some tolerance, but I think it is WAY less than things like LSD and mushrooms. I've heard of people doing multiple day sessions. In fact, if I'm not mistaken, it is sometimes taken that way traditionally in Peru. Also in the peyote meetings, I hear they just keep eating it during the whole meeting, which lasts all night.

Really? I don't get mushroom tolerance. I have taken mushrooms 3 days in a row without any tolerance issues. For me I think psilocin/psilocybin acts like DMT and does not built tolerance like other things. I never took cacti 2 days in a row so I don't know..but I have heard from others that rapid tolerance can build.

 

[DeDao]

I'd imagine there's some tolerance, but I think it is WAY less than things like LSD and mushrooms. I've heard of people doing multiple day sessions. In fact, if I'm not mistaken, it is sometimes taken that way traditionally in Peru. Also in the peyote meetings, I hear they just keep eating it during the whole meeting, which lasts all night.

Really? I don't get mushroom tolerance. I have taken mushrooms 3 days in a row without any toleranc issues. For me I think psilocin/psilocybin acts like DMT and does not built tolerance like other things. I never took cacti 2 days in a row so I don't know..but I have heard from others that rapid tolerance can build.

I have taken mushrooms multiple days in a row before. Never again will I do that.

First day I took like 1.5-2grams, had a decent experience. At the end of the week I had ingested 8-10grams with no further experience beyond the first day and maybe 50% reduced of the second.

Maybe it has to do with the body type and such. I always found LSD and mushrooms to have a very high tolerance rate.

 

[mew]

yes, theres a significant tolerance with both cacti and extracted mescaline. theres even cross tolerence between other phenethylamines and mescaline/cacti. example 3/4 g mesc did very very little after having taken 25i 2 days before, and 2ci the day before

i experienced this most drastically when i ate cacti for 10 out of 12 days
i find that if one and a half times the dose is roughly the tolerance increase to the second day

something to be considered is how much fasting the person has done before each "consecutive" dose, ie if they eat after the first experience and dose again the next morning they wont have fasted for a half day. this lack of fasting seems to correspond with weaker experiences

 

[BecometheOther]

Just recently i did cacti on a friday and then a few days later on sunday, and the experience on sunday (same dose) was an order of magnitude more satisfying and powerful.

I believe this was because we took the time to slow boil the brew, and ceremonially woke up the cactus brew with loud noises and chants and set up a very ritual atmosphere, and man did the cactus show up!

 

[Michal_R]

...(same dose)...

That´s quite interesting...

BecometheOther: What did you mean by "same dose"...?

 

[DeDao]

...(same dose)...

That´s quite interesting...

BecometheOther: What did you mean by "same dose"...?

What else could he have meant other than what he said?

If he took 18inches on day 1 he took 18inches on day two.

Although I agree with Mew's post. I believe it has to do with diet (fasting) and body composition. I have ALWAYS noticed very quick tolerance with psychedelics but they are quick to go away.

 

[Keeper Trout]

My guess is the differences involve differences in individual biochemistry.

For example, some people do not need much MAOI and other people require a massive amount to have similar effects with ayahuasca. I seem to have overactive MAO so for almost everything there seems to have less results for shorter periods than many people.
Anytime I've repeated the classical psychedelics, including cacti but not including DMT, a second day its taken much more material to get less effects. Day three has so far always been found to be a waste of good material. That is just my experience. I don't discount anyone else's results as all elements from sensitivity through dosage and tolerance development should be expected to exist as a range rather than being a set value. Tolerance development is rather well studied in both humans and animals and rapid development (and just as rapid a disappearance) of tolerance is common.
Its not the development of a true tolerance as occurs in the sense of opiates but seems to involve a short lived desensitization of receptors. Switching the molecules around can readily prolong the period in which a person gets good results.

I'd suggest that its a really lucky person who gets to enjoy multiple repeats of a single molecule for the same results. Their reports should not be rejected or ignored even if they are not the same as some other people's. Its diversity that keeps life interesting.
Folks with questions might want to step up to the plate and report back about their experiences following day three of using an identical dose of a single substance each day. It would be awesome to hear ten different people's accounts and compare/contrast them.
There is one other thing to consider. That being definitions. "Active" is a particularly vague word worth wrapping more words around.
When a person is getting good effects for days in a row it would be valuable to know their dosages and a description of the effects in order to be able to compare accounts. More detailed acounts of both elements might be helpful in finding better illumination? I've been especially curious that the amounts of isolated mescaline reported consumed by many people seems quite low.

 

[Michal_R]

I'd suggest that its a really lucky person who gets to enjoy multiple repeats of a single molecule for the same results...

Thats exactly why I asked what "same dose" meant, DeDao

The thing is that although it might have looked like "same dose" (volume-wise), yet the second dose might have been stronger in fact (due to sediments on the bottom, or whatever).