indeed!  But to some one new to the path this is 'real' and the way to get to the end of suffering (lack of self realization) is real is to realize it's impermanent and thus not self.

The paradox of it all is that it must be experienced.   Entheogens for me, when using mediation before, and during the trip has led to some amazing samdhi like experiences, but I don't think they are achievable by just eating a bunch of shrooms or smoking a bunch of DMT.  IMHO.    

At the end of the day though I hang my hat on science.  Science has pretty much proven as a matter-of-fact that everything in the material world is indeed impermanent.  By the time you read this word after the previous word the entire state of your body has changed and is no longer the same body that you previously identified with.  Yet you are strangely still here identifying with it all...pretty much means one thing if you get to the heart of it. 

You are not you material body.  You couldn't possible be or you would be destroyed and created every fraction of a second. One can learn to maintain a continuous awareness which means the self is something different.  Remember the Buddha never said there was no soul or a God...he just denied the permanence of them.  What ever that truly means my simply intellect has certainly not grasped in it'es entirety!   

At the end of the day I am spiritual because of science not in spite of it...and I find it utterly amazing that so much of what the Buddha taught is actually proven by moden science.  Of course not everything stacks up, but even buddha said to take everything he said with a grain of salt until you had convinced your own self of it's validity.

Peace