Need advise on using a microdose of Psilocybin with other Meds

[splaton]

Hello all I'm hoping to find some answers and hopefully improve my health.

Long story short regarding my health and medical history is that when i was 16 i had the misfortune of being diagnosed with a rare cancer called rhabdomyosarcoma which is extremely unusual and fatal in adults.

That being said i had to endure years of radiation and chemo (Red bag).... as a result of all the therapy I later on in life got hyperthyroidism (overactive thyroid) and im on a chronic medication called carbimazole to try and balance it, every now and then I go under and over active with my thyroid. (This took about 10 years to develop)

fast forward a few yours later, to just before covid i stated getting skin irritations which has now been diagnosed as eczema which as been awful, iv been on anti biotics for wounds and steriod creams for years however finally iv come across a specialist thats busy working to clear my skin and improve my eczema by giving me a medication called methotrexate.
So currently im on carbimazole and methotrexate however as in the title i was told that from an overall health perspective to deal with my insomnia, anxiety, concentration and immune system I should try psilocybin.

although not a medical forum ofc i would like to know if anyone knows if the psilocybin microdose can be used with these meds, i will take one psilocybin every 2 days in the morning.

From here im thinking of also taking lion's mane mushrooms?

Im just tired, i need my health back sight.

Thanks in advanced, looking forward to hear what the forums thinks.

P.S i hope this is in the right thread, it seems the most active.

 

[Sabnock1990]

I can't speak on the combination, but what i can say is that Methotrexate is essentially a Folate blocker, and to get your Folate you need to use either Folinic Acid, or Methylfolate and Methylcobalamin (or another good form of B12, not Cyanocobalamin). The reason being, Methotrexate degrades the DHFR enzyme which Folic Acid (which is found widely in supplements and enriched grain products) relies on to be metabolized first into Dihydrofolate and then into Tetrahydrofolate, which then the Tetrahydrofolate requires B6 for the SHMT enzyme to turn Tetrahydrofolate into it's metabolites. DHFR isn't the main enzyme that we're supposed to be getting our Folate from, and DHFR is a rate-limited enzyme and is easily saturated by Folic Acid which then causes unmetabolized Folic Acid to go into the bloodstream and the brain and can bind to/block the Folate Receptor Alpha and has some other imo detriments. By inhibiting/degrading the DHFR enzyme, Folic Acid will not be able to metabolize into the active Folate metabolites, and you will end up being Folate deficient, which has tons of detriments, especially for mental health, as well as physical health. Keep an eye on your fingernail moons/lunulas, imo/ime they are an indicator of Folate status in the body to some degree, it's either Folate or B12, and ime the fingernail moons respond to Folate rather than B12 but B12 is required because once Folate turns into Methylfolate the Methylfolate gets used along with B12 by Methionine Synthase to "restock" the Folate and SAM cycles, so Methylfolate gets converted back into Tetrahydrofolate which then goes back into the Folate cycle, and the methyl group from the Methylfolate goes to Cobalamin to make Methylcobalamin which is used to regenerate Methionine from Homocysteine and the Methionine then goes into the SAM cycle.

So long story short, if taking Folate blockers such as Methotrexate, and thus have little to no DHFR activity going on, you will need/require another source of Folate, whether natural dietary Folates, or Folinic Acid, or Methylfolate+B12, i recommend Methylfolate+B12.

 

[splaton]

I can't speak on the combination, but what i can say is that Methotrexate is essentially a Folate blocker, and to get your Folate you need to use either Folinic Acid, or Methylfolate and Methylcobalamin (or another good form of B12, not Cyanocobalamin). The reason being, Methotrexate degrades the DHFR enzyme which Folic Acid (which is found widely in supplements and enriched grain products) relies on to be metabolized first into Dihydrofolate and then into Tetrahydrofolate, which then the Tetrahydrofolate requires B6 for the SHMT enzyme to turn Tetrahydrofolate into it's metabolites. DHFR isn't the main enzyme that we're supposed to be getting our Folate from, and DHFR is a rate-limited enzyme and is easily saturated by Folic Acid which then causes unmetabolized Folic Acid to go into the bloodstream and the brain and can bind to/block the Folate Receptor Alpha and has some other imo detriments. By inhibiting/degrading the DHFR enzyme, Folic Acid will not be able to metabolize into the active Folate metabolites, and you will end up being Folate deficient, which has tons of detriments, especially for mental health, as well as physical health. Keep an eye on your fingernail moons/lunulas, imo/ime they are an indicator of Folate status in the body to some degree, it's either Folate or B12, and ime the fingernail moons respond to Folate rather than B12 but B12 is required because once Folate turns into Methylfolate the Methylfolate gets used along with B12 by Methionine Synthase to "restock" the Folate and SAM cycles, so Methylfolate gets converted back into Tetrahydrofolate which then goes back into the Folate cycle, and the methyl group from the Methylfolate goes to Cobalamin to make Methylcobalamin which is used to regenerate Methionine from Homocysteine and the Methionine then goes into the SAM cycle.

So long story short, if taking Folate blockers such as Methotrexate, and thus have little to no DHFR activity going on, you will need/require another source of Folate, whether natural dietary Folates, or Folinic Acid, or Methylfolate+B12, i recommend Methylfolate+B12.

hey thanks for such detailed info i really appreciate it. Iv been trying to google interactions but cant seem to find anything in general but this bit of info really shines a light on how the meds work

 

[Transform]

Not a medical practitioner here, but those two medications don't appear to me to have any particular contraindication with psilocybin. Taking care of your B-vitamin levels will make for a happier nervous system, which in turn should make for a more beneficial psilocybin experience. Psychedelics are a complement to, rather than a substitute for, good nutrition.