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I think the bottom line as far as consuming separately is the individual. Although 45 minutes is probably way too long for anyone.

My successful pharmahuasca was separated by 20 minutes. Harmaline HCl dissolved in water, followed 20 minutes later by DMT citrate dissolved in water. I could feel the DMT kicking in no more than 10 minutes after ingestion. My traditional Ayahuasca consumption took around 20 minutes to feel. This leads me to believe that DMT was being destroyed by MAO enzymes for a good 5-10 minutes.

But really the whole point of separate ingestion is simply to give the MAOI a head start. 5 minutes is probably plenty of time.

[QUOTE="syberdelic, post: 3772481, member: 34856"] I think the bottom line as far as consuming separately is the individual. Although 45 minutes is probably way too long for anyone. My successful pharmahuasca was separated by 20 minutes. Harmaline HCl dissolved in water, followed 20 minutes later by DMT citrate dissolved in water. I could feel the DMT kicking in no more than 10 minutes after ingestion. My traditional Ayahuasca consumption took around 20 minutes to feel. This leads me to believe that DMT was being destroyed by MAO enzymes for a good 5-10 minutes. But really the whole point of separate ingestion is simply to give the MAOI a head start. 5 minutes is probably plenty of time. [/QUOTE]